Advances in polyvinyl alcohol hydrogel keratoprostheses: Protection against ultraviolet light and fabrication by a molding process

Tsuk, Andrew G.; Trinkaus‐Randall, Vickery; Leibowitz, Howard M.

doi:10.1002/(sici)1097-4636(19970305)34:3<299::aid-jbm4>3.0.co;2-f

Cited by 21 publications

(8 citation statements)

References 2 publications

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“…For the peripheral component, we used a blown microfiber polybutylene/ polypropylene blend (80:20). The molding of the 2 parts is described in detail in Tsuk et al (1). Three separate models and surgeries were evaluated.…”

Section: Materials For Devicementioning

confidence: 99%

“…Alternatively, corneal transplants are needed in several third world countries where donor corneas are not culturally acceptable. Devices have been implanted since the 1700s with the goal of giving recipients finger counting vision (1). However, these were not incorporated into the cornea and often became extruded.…”

mentioning

confidence: 99%

“…However, these were not incorporated into the cornea and often became extruded. Renewed interest in the development of synthetic corneas has led to the fabrication of several designs based on a central hydrogel and a porous skirt where fibroplasia can occur and anchor the device in place (1)(2)(3).…”

mentioning

confidence: 99%

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Implantation of a Synthetic Cornea: Design, Development and Biological Response

Trinkaus‐Randall

Tablante

et al. 1997

Artificial Organs

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Our goal was to evaluate 3 different designs of synthetic corneas in vivo. All devices had a transparent hydrogel center molded to a porous peripheral skirt. Over 30 devices were implanted into rabbits and followed for up to 6 months. The devices were preseeded with rabbit stroma1 fibroblasts, which enhanced the rate of fibroplasia. The anterior surface of the hydrogel was modified using argon rf plasma treatments. Clinical examinations were performed, and histological analyses were conducted on tissue throughout the time course. Our optimal model ranged from 4.5 to 6 mm and had an extended porous skirt increasing the surface area for fibroplasia and ultimate anchorage of the device. Fibroplasia occurred in this model, and collagen was detected by 28 days. The anterior chamber was normal with no detectable leakage of aqueous humor. Glycosaminoglycans were detected and followed the time course outlined previously when porous material itself was inserted into the stroma. We present the first demonstration that rabbit limbal epithelial cells can migrate onto the synthetic cornea in vivo.

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Section: Materials For Devicementioning

confidence: 99%

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confidence: 99%

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Implantation of a Synthetic Cornea: Design, Development and Biological Response

Trinkaus‐Randall

Tablante

et al. 1997

Artificial Organs

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“…While the advent of the Boston and AlphaCor keratoprostheses, as well as other innovative prosthetic designs (Cardona, 1991;Hille et al, 2002;Pintucci et al, 1996;Strampelli, 1972;Tsuk et al, 1997), represent significant milestones toward the development of a more biomimetic artificial cornea, their shortcomings have highlighted design parameters that need to be addressed for the long-term safety and stability of these devices. In general, a number of complications have limited their widespread applicability.…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct

Myung

Koh

Bakri

et al. 2007

Biomed Microdevices

110

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We describe the design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct, and demonstrate the adhesion of corneal epithelial and fibroblast cells to its central and peripheral components, respectively. The design consists of a central "core" optical component and a peripheral tissue-integrable "skirt." The core is composed of a poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) double-network with high strength, high water content, and collagen type I tethered to its surface. Interpenetrating the periphery of the core is a microperforated, but resilient poly(hydroxyethyl acrylate) (PHEA) hydrogel skirt that is also surface-modified with collagen type I. The well-defined microperforations in the peripheral component were created by photolithography using a mask with radially arranged chrome discs. Surface modification of both the core and skirt elements was accomplished through the use of a photoreactive, heterobifunctional crosslinker. Primary corneal epithelial cells were cultured onto modified and unmodified PEG/PAA hydrogels to evaluate whether the central optic material could support epithelialization. Primary corneal fibroblasts were seeded onto the PHEA hydrogels to evaluate whether the peripheral skirt material could support the adhesion of corneal stromal cells. Cell growth in both cases was shown to be contingent on the covalent tethering of collagen. Successful demonstration of cell growth on the two engineered components was followed by fabrication of core-skirt constructs in which the central optic and peripheral skirt were synthesized in sequence and joined by an interpenetrating diffusion zone.

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“…[4][5][6][7] Small perforations (<1.5 mm) are mainly repaired by tissue adhesives, whereas large perforations are usually closed by a corneal allograft. [8][9][10][11][12] The aim of this study was to investigate whether a tailored polymeric biomaterial could be used for closing medium-sized corneal perforations. Such a practice would, at least in principle, avoid the problem that healthy tissue is excised in order to accommodate an oversized implant.…”

Section: Introductionmentioning

confidence: 99%

Tailoring of New Polymeric Biomaterials for the Repair of Medium-Sized Corneal Perforations

et al. 2000

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The aim of this study was to investigate whether polymeric biomaterials can be designed such that they become suitable for surgical closure of medium-sized perforations in the cornea, the transparent tissue in the front of the eye. Such a biomaterial must meet stringent requirements in terms of hydrophilicity, strength, transparency, flexibility, and biocompatibility. Four different copolymers of n-butyl methacrylate (BMA) and hexa(ethylene glycol) methacrylate (HEGMA) were prepared and characterized. Poly(BMA) was made as a reference material. Physicochemical properties were measured (contact angles, glass-transition temperatures, thermal degradation, water uptake and swelling), and cytotoxicity in vitro was assessed with a MTT test. Moreover, the interaction between the materials and cultured human corneal epithelial cells was studied. The copolymers may be useful for temporary closure of corneal perforations.

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Advances in polyvinyl alcohol hydrogel keratoprostheses: Protection against ultraviolet light and fabrication by a molding process

Cited by 21 publications

References 2 publications

Implantation of a Synthetic Cornea: Design, Development and Biological Response

Implantation of a Synthetic Cornea: Design, Development and Biological Response

Design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct

Tailoring of New Polymeric Biomaterials for the Repair of Medium-Sized Corneal Perforations

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