Advances in repetitive transcranial magnetic stimulation for posttraumatic stress disorder: A systematic review

Belsher, Bradley E.; Beech, Erin H.; Reddy, Madhavi K.; Smolenski, Derek J.; Rauch, Sheila A.M.; Kelber, Marija Spanovic; Issa, Fuad; Lewis, Catrin; Bisson, Jonathan I.

doi:10.1016/j.jpsychires.2021.05.011

Cited by 21 publications

(19 citation statements)

References 74 publications

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“…A systematic review of studies was performed by Belsher et al in 2021 which looked at the use of rTMS for PTSD ( 20 ). This review looked at 13 studies with 549 participants and the authors compared the effects of rTMS verus sham, high-frequency verses low-frequency rTMS on posttreatment PTSD scores using calculated standardized mean differences (SMD).…”

Section: Clinical Studies: Efficacy and Safetymentioning

confidence: 99%

“…This review looked at 13 studies with 549 participants and the authors compared the effects of rTMS verus sham, high-frequency verses low-frequency rTMS on posttreatment PTSD scores using calculated standardized mean differences (SMD). The authors concluded that at posttreatment rTMS was superior to shame in reducing PTSD symptoms (SMD = −1.13 95% CI [−2.10–−0.15]) ( 20 ). However, they also concluded that the quality of their analysis was rated as very low due to small sample sizes, treatment heterogeneity, inconsistent results, and an imprecise pooled effect.…”

Section: Clinical Studies: Efficacy and Safetymentioning

confidence: 99%

“…High-frequency rTMS was associated with slightly improved outcomes compared to low-frequency rTMS on PTSD, however, this was also imprecise. They concluded that further research is required to further delineate the effects of rTMS on PTSD ( 20 ). Table 1 is a summary of the studies discussed in this section.…”

Section: Clinical Studies: Efficacy and Safetymentioning

confidence: 99%

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Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder

et al. 2022

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Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes significant functional impairment and is related to altered stress response and reinforced learned fear behavior. PTSD has been found to impact three functional networks in the brain: default mode, executive control, and salience. The executive control network includes the dorsolateral prefrontal cortex (DLPFC) and lateral PPC. The salience network involves the anterior cingulate cortex, anterior insula, and amygdala. This latter network has been found to have increased functional connectivity in PTSD. Transcranial Magnetic Stimulation (TMS) is a technique used in treating PTSD and involves stimulating specific portions of the brain through electromagnetic induction. Currently, high-frequency TMS applied to the left dorsolateral prefrontal cortex (DLPFC) is approved for use in treating major depressive disorder (MDD) in patients who have failed at least one medication trial. In current studies, high-frequency stimulation has been shown to be more effective in PTSD rating scales posttreatment than low-frequency stimulation. The most common side effect is headache and scalp pain treated by mild analgesics. Seizures are a rare side effect and are usually due to predisposing factors. Studies have been done to assess the overall efficacy of TMS. However, results have been conflicting, and sample sizes were small. More research should be done with larger sample sizes to test the efficacy of TMS in the treatment of PTSD. Overall, TMS is a relatively safe treatment. Currently, the only FDA- approved to treat refractory depression, but with the potential to treat many other conditions.

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Section: Clinical Studies: Efficacy and Safetymentioning

confidence: 99%

Section: Clinical Studies: Efficacy and Safetymentioning

confidence: 99%

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Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder

et al. 2022

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“…In particular, the causal human connectome highlights high connectivity of the frontoparietal network with all other higher cognitive RSNs. The discovered hub role of the frontoparietal network in the causal human connectome is especially attractive, as brain-based therapies for psychiatric conditions typically impact or directly stimulate nodes in the frontoparietal network (Belsher et al, 2021;Ferrarelli and Phillips, 2021;Fitzgerald, 2021;Song et al, 2019;Voigt et al, 2021;Zhang et al, 2021;Zilverstand et al, 2017Zilverstand et al, , 2016. Previously, we even demonstrated that connectivity in the frontoparietal network has downstream causal effects on the severity of alcohol use disorder (Rawls et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

The Resting-State Causal Human Connectome is Characterized by Hub Connectivity of Executive and Attentional Networks

Rawls

Kummerfeld

Mueller

et al. 2021

Preprint

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We introduce a data-driven causal discovery method (Greedy Adjacencies and Non-Gaussian Orientations; GANGO) for calculating a "causal connectome" of directed connectivity from resting-state fMRI data and characterizing hubs of directed information transfer across the human cortex. Prominent hubs of the causal connectome were situated in attentional (dorsal attention) and executive (frontoparietal and cingulo-opercular) networks. These hub networks had distinctly different connectivity profiles. Attentional networks shared incoming connections with sensory regions and outgoing connections with higher cognitive networks, while executive networks primarily connected to other higher cognitive networks and had a high degree of bidirected connectivity. Virtual lesion analyses accentuated these findings, demonstrating that attentional and executive hubs are points of critical vulnerability in the human causal connectome. These data highlight the central role of attention and executive control networks in the human cortical connectome and set the stage for future applications of data-driven causal ("effective") connectivity analysis in psychiatry.

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“…Kürzlich publizierte Übersichtsartikel und Metaanalysen belegen die Wirksamkeit der oben skizzierten TMS-Techniken für die Behandlung von PTBS, Depressionen und verschiedenen anderen Ängsten 12 , 13 , 14 . Diese Metaanalysen berichten gute bis sehr gute Behandlungserfolge im Vergleich zu Kontrollstimulationen (sogenannte Sham-Stimulationen, bei denen die Spule an der Schädeloberfläche umgedreht wird, damit der TMS-Impuls nicht ins Gehirn geleitet wird).…”

Section: Nicht-invasive Stimulationstechnikenunclassified

Stimulationsverfahren und Neurofeedback: neue Möglichkeiten zur Therapie und Rehabilitation?

Jäncke¹

2021

PiD - Psychotherapie im Dialog

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Das Gehirn des Menschen bestimmt unser Denken, Handeln und Fühlen. Ebenso wie außergewöhnliche kognitive und motorische Leistungen werden psychiatrische und psychopathologische Probleme durch neurophysiologische und neuroanatomische Besonderheiten des Gehirns bestimmt. Eine Idee, psychische oder neurologische Störungen zu behandeln ist, die Gehirnaktivität durch unterschiedliche invasive oder nicht-invasive Verfahren zu beeinflussen.

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Advances in repetitive transcranial magnetic stimulation for posttraumatic stress disorder: A systematic review

Cited by 21 publications

References 74 publications

Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder

Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder

The Resting-State Causal Human Connectome is Characterized by Hub Connectivity of Executive and Attentional Networks

Stimulationsverfahren und Neurofeedback: neue Möglichkeiten zur Therapie und Rehabilitation?

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