Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Zheng, Youle; Feng, Jin; Yu, Yixin; Ling, Min; Wang, Xu

doi:10.1007/s12272-024-01493-2

Arch. Pharm. Res.

2024

DOI: 10.1007/s12272-024-01493-2

|View full text |Cite

Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Youle Zheng,

Jin Feng,

Yixin Yu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 7 publications

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Glycyrrhiza uralensis extract improves dexamethasone-induced sarcopenia via regulating myostatin- and FoxO3a-mediated E3 ubiquitin ligase

Zheng,

An,

Kim

et al. 2024

Food Bioscience

View full text Add to dashboard Cite

Glycyrrhiza uralensis extract improves dexamethasone-induced sarcopenia via regulating myostatin- and FoxO3a-mediated E3 ubiquitin ligase

Zheng,

An,

Kim

et al. 2024

Food Bioscience

View full text Add to dashboard Cite

Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets

Ali,

Nkembo,

Tipparaju

et al. 2024

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Sarcopenia, a disorder marked by muscle loss and dysfunction, is a global health concern, particularly in aging populations. Sarcopenia is intricately related to various health conditions, including obesity, dysphagia, and frailty which underscore the complexity. Despite recent advances in metabolomics and other omics data for early detection and treatment, the precise characterization and diagnosis of sarcopenia remains challenging. In the present review we provide an overview of the complex metabolic mechanisms that underlie sarcopenia, with particular emphasis on protein, lipid, carbohydrate, and bone metabolism. The review highlights the importance of leucine and other amino acids in promoting muscle protein synthesis and clarifies the critical role played by amino acid metabolism in preserving muscular health. In addition, the review provides insights regarding lipid metabolism on sarcopenia, with an emphasis on the effects of inflammation and insulin resistance. The review also emphasizes the complex relationship between bone and muscle health by highlighting the interaction between sarcopenia and bone metabolism. Furthermore, the review outlines various therapeutic approaches and potential biomarkers for diagnosing sarcopenia. These include pharmacological strategies such as hormone replacement therapy and anabolic steroids as well as lifestyle modifications such as exercise, nutrition, and dietary changes.

show abstract

Sarcopenia and frailty among older Chinese adults: Findings from the CHARLS study

Xu,

Cai,

Liu

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Sarcopenia and frailty are common among elderly individuals and present substantial health hazards. Exploring their relationship is essential for optimizing geriatric healthcare, particularly within the context of China. Methods A population-based cross-sectional design was employed using data from the China Health and Retirement Longitudinal Study (CHARLS). The study enrolled 5,714 participants aged ≥60 years who underwent assessment for sarcopenia following the criteria established by the Asia Working Group for Sarcopenia (AWGS 2019) in 2019. Frailty status was determined using a frailty index that categorized participants into robustness, pre-frailty, and frailty stages. Multivariable logistic regression models were employed to examine the relationship between sarcopenia and frailty and pre-frailty conditions. Subgroup and interaction analyses were performed to explore the robustness of the associations between sarcopenia and frailty across different subgroups. Results Among the participants, 1,028 (18.0%) were identified as frailty, 2,987 (52.3%) as pre-frailty, and 645 (11.3%) had sarcopenia. Sarcopenia demonstrated an independent association with higher risks of frailty (OR = 2.13, 95% CI: 1.52–2.99) and pre-frailty (OR = 1.42, 95% CI: 1.20–1.81) in the multivariable logistic analysis. Subgroup and interaction analyses consistently demonstrated significant associations across nearly all demographic and health-related subgroups. Conclusions This study highlights that sarcopenia is significantly and independently associated with frailty and pre-frailty among older adults in China. Early detection and targeted interventions for sarcopenia are crucial to mitigate frailty and its adverse health outcomes in aging populations, emphasizing the need for tailored healthcare strategies to promote healthy aging.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Cited by 7 publications

References 188 publications

Glycyrrhiza uralensis extract improves dexamethasone-induced sarcopenia via regulating myostatin- and FoxO3a-mediated E3 ubiquitin ligase

Glycyrrhiza uralensis extract improves dexamethasone-induced sarcopenia via regulating myostatin- and FoxO3a-mediated E3 ubiquitin ligase

Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets

Sarcopenia and frailty among older Chinese adults: Findings from the CHARLS study

Contact Info

Product

Resources

About