Curcumin (CUR, 1,7-diphenyl-1,6-heptadiene-3,5-dione) is a natural crystalline polyphenol extracted from the rhizome of turmeric plants. It is often used in supplements or as a preservative and food colorant due to its strong yellow color. Its multiple biological properties include anticarcinogenic, antioxidant, anti-inflammatory, and antimicrobial activities; these are mostly due to the presence of βdione and keto-enol interconversion structures able to scavenge oxygen free radicals (Tai et al., 2020). Despite its biological activities, extremely poor solubility in aqueous solutions, very low oral bioavailability and easy degradability hinder its direct incorporation in several food products. In addition, curcumin presents a high metabolic rate and rapid excretion, which decreases its absorption in the human body (Wang et al., 2021). Vitamin D 3 (VD3, cholecalciferol) is a fat-soluble bioactive substance synthesized in human skin after sunlight exposure. It presents steroid hormone function and plays important roles in calcium and phosphorus homeostasis and bone health and in the inhibition of cardiovascular diseases, different types of cancer and diabetes