Advances in Spray Drying Technology for Nanoparticle Formation

Development of Simvastatin-Loaded Particles Using Spray Drying Method for Ex Tempore Preparation of Cartridges for 2D Printing Technology

“…Nevertheless, a higher temperature should primarily lead to a higher Peclet number and thus larger particles [36,37]. However, the Peclet number can be manipulated by the evaporation rate of the chosen solvent and the diffusional coefficients of the solutes we use in the formulation [28], which may lead to a different result that is in better agreement with our result [28,38,39].…”

Microencapsulation of green coffee oil: Encapsulation efficiency, morphology, and bioactive compound retention

“…However, sample F4 could not be sprayed by the piezoelectric nozzle because its high solids content increased the emulsion viscosity to approximately 25 cP (Figure 2), reducing its ability to be sprayed through the piezoelectric atomizing nozzle. Wong and John (2016) reported that the piezoelectric atomizing nozzle may be able to spray liquids with low solids content or low viscosity, i.e., the feed viscosity of the liquid should be lower than 10 cP. According to this, sample F4 was diluted (one part of emulsion with two parts of water) until approximately 5 cP before drying to ensure to be below the limits set by the nanospray dryer.…”

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

“…The solid nanoparticles are prepared by solvent evaporation emulsification technique or ionic gelation of oppositely charged materials in the liquid state, followed by freeze drying or spray drying process ( Agnihotri et al, 2004 ; Rawal et al, 2017 ; Yildiz-Peköz et al, 2018 ). Alternatively, they are produced by directly spray drying a solution feed of drugs and excipients through effectively controlling the process parameters such as inlet temperature, liquid feed flow rate, atomizing gas pressure, heating air flow, nozzle geometry and cyclone performance ( Noraizaan & Wong, 2017 ; Wong & John, 2016 ). The solid nanoparticles are known to be exhalation prone and highly aggregative, and these hinder their dispersion and inhalation performance ( Muralidharan et al, 2015 ; Yang et al, 2008 ).…”