Advances in stem cell research for the treatment of male sexual dysfunctions

Soebadi, Mohammad Ayodhia; Moris, Lisa; Castiglione, Fabio; Weyne, Emmanuel; Albersen, Maarten

doi:10.1097/mou.0000000000000255

Cited by 36 publications

(22 citation statements)

References 73 publications

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“…Several types of MSCs, such as BM-MSC and adipose tissue-derived stem cells are capable of differentiation into endothelial cells, cavernous smooth muscle cells and neurons. This latter ability of SCs has been used with positive effects to treat ED in animal models [23,24].…”

Section: Discussionmentioning

confidence: 99%

Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial

et al. 2018

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Objectives: This open label, phase I clinical trial (NCT02945462) using 2 consecutive intracavernous autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) for the first time in the treatment of diabetic patients with erectile dysfunction (ED). The primary outcome is to assess the safety and tolerability of intracavernous autologous BM-MSCs, the secondary outcome is to assess efficacy of the procedure. Patients and Methods: Four diabetic patients with refractory ED were included. Two consecutive intracavernous autologous BM-MSC injections were performed. Tolerability was assessed immediately and at 24 h, safety was evaluated for 2 years. Efficacy was assessed using International Index of Erectile Function-15 (IIEF-15) and Erection Hardness Score (EHS) for 12 months. Results: procedure was well tolerated and no patients reported significant adverse effects. There was significant improvement of IIEF-15 and EHS; IIEF-15 (p = 0.04), Erectile Function (p = 0.03), Sexual Desire (p = 0.04), Intercourse Satisfaction (p = 0.04), and Overall Satisfaction (p = 0.04). Conclusion: This is the first human study with proven tolerability, safety and efficacy of intracavernous autologous BM-MSC injections for treatment of diabetic patients with ED.

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Section: Discussionmentioning

confidence: 99%

Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial

et al. 2018

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“…damage. There is a lack of evidence of engraftment or even differentiation of the cells in vivo [3] and mounting evidence suggests stem cell mediated repair by paracrine effect rather than stem cell differentiation [4]. In vivo findings suggest a paracrine mechanism being responsible for the regeneration, as treatment with ADRC-lysate alone improves EF in a rat nerve crush injury model [5].…”

mentioning

confidence: 99%

A 12-Month Follow-up After a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial

Haahr

Jensen

Toyserkani

et al. 2018

Urology

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“…A recent article by Soebadi et al [7] published in 2016 summarized all of2017-01-03 these studies. These authors described the many preclinical trials that have provided data on the utilization of both bone marrow stem cells and adipose-derived stem cells (ADSCs) for ED.…”

Section: Role Of Stem Cells In the Treatment Of Erectile Dysfunctionmentioning

confidence: 99%

“…In acute ED models, the mechanism of action of stem cells is presumed to be by paracrine action [373839]. In contrast, in chronic ED, the theoretical method of stem cell action is postulated to be both engraftment and cellular differentiation [7]. However, the exact mechanism of action of stem cells in chronic ED remains uncertain [40].…”

Section: Role Of Stem Cells In the Treatment Of Erectile Dysfunctionmentioning

confidence: 99%

“…With the exceptions of lifestyle modification and revascularization procedures, these methods merely treat the manifestations of ED, offering symptomatic relief rather than a cure for the underlying disease process. The pressing need to develop a curative treatment for ED has stimulated interest in utilizing stem-cell therapy in ED patients [7]. …”

Section: Introductionmentioning

confidence: 99%

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The Current Status of Stem-Cell Therapy in Erectile Dysfunction: A Review

Reed‐Maldonado

Lue

2016

World J Mens Health

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Stem cells are undifferentiated cells that are capable of renewal and repair of tissue due to their capacity for division and differentiation. The purpose of this review is to describe recent advances in the use of stem cell (SC) therapy for male erectile dysfunction (ED). We performed a MEDLINE database search of all relevant articles regarding the use of SCs for ED. We present a concise summary of the scientific principles behind the usage of SC for ED. We discuss the different types of SCs, delivery methods, current pre-clinical literature, and published clinical trials. Four clinical trials employing SC for ED have been published. These articles are summarized in this review. All four report improvements in ED after SC therapy. SC therapy remains under investigation for the treatment of ED. It is reassuring that clinical trials thus far have reported positive effects on erectile function and few adverse events. Safety and methodical concerns about SC acquisition, preparation and delivery remain and require continued investigation prior to wide-spread application of these methods.

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Advances in stem cell research for the treatment of male sexual dysfunctions

Abstract: Evidence from preclinical studies has established stem cells as a potential curative treatment for erectile dysfunction and early phase clinical trials are currently performed.

Cited by 36 publications

References 73 publications

Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial

Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial

A 12-Month Follow-up After a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial

The Current Status of Stem-Cell Therapy in Erectile Dysfunction: A Review

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