Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide

Abstract

Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory and analgesic, antitumor, antimicrobial, anticonvulsant, among others. The most well known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide, because this compound initially presented important sedative effects. This review approaches some of the recent and efficient chemical synthesis pathway to obtain phthalimide analogues. It is also presented a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.

Synthesis and biological activities of new phthalimide and thiazolidine derivatives

“…Despite its initial successful clinical results, its use by pregnant women was discontinued because of teratogenic properties. This compound caused severe malformations in the children of women who took the drug during pregnancy [10,11].…”

“…Phthalimide pharmacophoric group has been reported in the literature for several biological activities, such as antiinflammatory activity [12,13], antitumor activity [14,15], analgesic [16], anticonvulsant [17], antituberculosis [18], hypolipemic [19], α-glucosidase inhibitory activity [20], among other activities [11].…”

Design, Synthesis and Biological Activities of New Phthalimide and Thiazolidine Derivatives

“…Despite its initial successful clinical results, its use has been discontinued because of teratogenic properties. This compound caused severe malformations in the children of women who took the drug during pregnancy [10,11].…”

“…Phthalimide pharmacophoric group has been reported in the literature for several biological activities, such as anti-in ammatory activity [12,13], antitumor activity [14,15], analgesic [16], anticonvulsant [17], antituberculosis [18], hypolipemic [19], α-glucosidase inhibitory activity [20], among other activities [11].…”

Design, Synthesis and Biological Activities of New Phthalimide and Thiazolidine Derivatives

“…Phthalimide pharmacophoric group has been reported in the literature for several biological activities, such as anti-in ammatory activity [12,13], antitumor activity [14,15], analgesic [16], anticonvulsant [17], antituberculosis [18], hypolipemic [19], α-glucosidase inhibitory activity [20], among other activities [11].…”