Advances in the antimicrobial treatment of osteomyelitis

Zhong, Chao; Wu, Yueming; Lin, Haodong; Liu, Runhui

doi:10.1016/j.compositesb.2022.110428

Cited by 34 publications

(11 citation statements)

References 287 publications

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“…A study employing HAp as a carrier loaded with ciprofloxacin demonstrated notable antimicrobial activity, effectively enhancing the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells [ 54 ]. Commonly utilized antibiotics for bone infection therapy include gentamicin, vancomycin, and zyvox (linezolid) [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

The Preparation and Characterization of Chitosan/Calcium Phosphate Composite Microspheres for Biomedical Applications

Wu,

Huang,

Kao

et al. 2024

Polymers

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In this study, we successfully prepared porous composite microspheres composed of hydroxyapatite (HAp), di-calcium phosphate di-hydrated (DCPD), and chitosan through the hydrothermal method. The chitosan played a crucial role as a chelating agent to facilitate the growth of related calcium phosphates. The synthesized porous composite microspheres exhibit a specific surface area of 38.16 m2/g and a pore volume of 0.24 cm3/g, with the pore size ranging from 4 to 100 nm. Given the unique properties of chitosan and the exceptional porosity of these composite microspheres, they may serve as carriers for pharmaceuticals. After being annealed, the chitosan transforms into a condensed form and the DCPD transforms into Ca2P2O7 at 300 °C. Then, the Ca2P2O7 initially combines with HAp to transform into β tricalcium phosphate (β-TCP) at 500 °C where the chitosan is also completely combusted. Finally, the microspheres are composed of Ca2P2O7, β-TCP, and HAp, also making them suitable for applications such as injectable bone graft materials.

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Section: Introductionmentioning

confidence: 99%

The Preparation and Characterization of Chitosan/Calcium Phosphate Composite Microspheres for Biomedical Applications

Wu,

Huang,

Kao

et al. 2024

Polymers

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“…Surgical debridement and antibiotic treatment are the most conventional clinical approaches to treat bacterial infection. [ 46 ] In particular, surgical debridement is an effective method to treat bacterial infections that mainly involve biofilm infection or subcutaneous abscesses caused by bacterial infection. However, surgical debridement is not effective for bacterial infection treatment because the bacteria are small and easily remain.…”

Section: Current Clinical Strategiesmentioning

confidence: 99%

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Yang,

Song,

Dong

et al. 2023

Small

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Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always‐on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment‐responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli‐actuated turn‐on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.

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“…At the site of infection, pathogens can produce bacterial toxins that severely damage blood vessels and bone tissue, preventing antibiotics from penetrating the infected area and accelerating bone destruction [ 7 ]. In recent years, various materials used in the treatment of osteomyelitis have achieved satisfactory results [ 8 , 9 ], but there are still some deficiencies, such as secondary injury of material removal, metabolic toxicity of material in vivo, and its specific molecular mechanism is unknown. Nanoparticles are designed as nanoscale (1–100 nm) synthetic building blocks for drug delivery, construct scaffold to fill the repair promoting factor and other medical applications [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Size-dependent gold nanoparticles induce macrophage M2 polarization and promote intracellular clearance of Staphylococcus aureus to alleviate tissue infection

Peilin,

Ying,

Renyuan

et al. 2023

Materials Today Bio

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Advances in the antimicrobial treatment of osteomyelitis

Cited by 34 publications

References 287 publications

The Preparation and Characterization of Chitosan/Calcium Phosphate Composite Microspheres for Biomedical Applications

The Preparation and Characterization of Chitosan/Calcium Phosphate Composite Microspheres for Biomedical Applications

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Size-dependent gold nanoparticles induce macrophage M2 polarization and promote intracellular clearance of Staphylococcus aureus to alleviate tissue infection

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