Advances in the application of metal–organic framework nanozymes in colorimetric sensing of heavy metal ions

Abstract

Nanozymes, which can be defined as nanomaterials with excellent catalytic function, are well-known to the scientific community due to their distinct merits, such as low cost and high stability, which...

Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application

“…Over the last few years, numerous MOFs have been successfully developed to mimic the peroxidase (POX), oxidase (OX), superoxide dismutase (SOD), and catalase (CAT) activities of natural enzymes. Interestingly, some of the developed MOFs could also mimic two or While several reviews on the nanozyme activity of MOFs exist in the literature, most of these reviews have primarily focused on general classifications, construction mechanisms, and applications of MOF-NZs within specific domains, such as biosensing [34,54,55], cancer therapy [56,57], or theranostics [43]. MOF-NZs, however, can be utilized in a rather large number of applications and a review encompassing these applications would imply their tremendous potential and be timely.…”

“…To date, several MOFs have been reported to show intrinsic peroxidase-mimic activity, such as Material Institute of Lavoisier (MIL)-53 (20), MIL-100(Fe) (21), MIL-100(Al)-NH 2 (19), and Hong Kong University of Science and Technology (HKUST)-1 [61]. These redox couples catalytically activate H 2 O 2 by employing a Fenton-like reaction to produce a hydroxyl radical ( • OH) and thus render MOFs to oxidize chromogenic POX substrates (Figure 2A,B) [55,62]. In one such report, Cu(II)-MOFs were designed using 4,4 ′ -bipyridine as organic linkers and Cu(II) as the active metallic center by employing a self-assembly strategy [62].…”

“…Thanks to the diversity and structural tunability of MOF-based materials, MOF-based nanozymes (MOF-NZs) simulating a variety of enzyme-like activities have been developed and applied in various biomedical fields (Figure 1). While several reviews on the nanozyme activity of MOFs exist in the literature, most of these reviews have primarily focused on general classifications, construction mechanisms, and applications of MOF-NZs within specific domains, such as biosensing [34,54,55], cancer therapy [56,57], or theranostics [43]. MOF-NZs, however, can be utilized in a rather large number of applications and a review encompassing these applications would imply their tremendous potential and be timely.…”

Antibacterial, antibiofilm, and antioxidant activities of two novel metal–organic frameworks (MOFs) based on 4,6-diamino-2-pyrimidinethiol with Zn and Co metal ions as coordination polymers

“…12,13 MOFs play a crucial role in catalytic activity because of their notable characteristics, such as high porosity, large surface area, tunable chemical composition, diverse functions, and inherent biodegradability. 14 These materials have been applied in biomedical and environmental sectors, including chemical sensing, 15 bio-imaging, 16 drug delivery, 17 their uses against FRs and bacterial species, 18 designing nanozymes, 19 and environmental remediation such as water purication. 20 Based on their applications and uses, MOFs can be categorized based on different criteria, such as the characteristics of their metal ions, the type of organic linkers, porosity, functionality, topology, and dimensionality of their network.…”