Advances in the application of hydrogel-based scaffolds for tendon repair

Chen, Renqiang; Chen, Fanglin; Chen, Kenian; Xu, Jian

doi:10.1016/j.gendis.2023.04.039

Cited by 2 publications

(1 citation statement)

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“…Tendon tissue engineering includes seed cells, bioactive factors and, most importantly, scaffold materials. Appropriate scaffolds not only maintain the biomechanical properties of the tendon, but also provide a good environment for seed cell growth and proliferation [ 27 ]. Accordingly, biologically derived materials such as ECM are currently used in tissue engineering, with TECM being used in the repair of injured tendons [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Tendon extracellular-matrix-derived tissue engineering micro-tissue for Achilles tendon injury regeneration in rats

Zhang,

Shi

et al. 2024

J Orthop Surg Res

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Background Achilles tendon is vital in maintaining the stability and function of ankle joint. It is quite difficult to achieve the structural and functional repair of Achilles tendon in tissue engineering. Methods A tissue-engineered tendon micro-tissue was prepared using rat tail tendon extracellular matrix (TECM) combined with rat adipose stem cells (ADSCs) to repair Achilles tendon injuries. The TECM was prepared by repeated freezing and thawing. The in vitro characteristics of TECM and its effect on ADSCs proliferation were detected. This tissue-engineered tendon micro-tissue for Achilles tendon repair in vivo was evaluated based on general characteristics, gait analysis, ultrasound findings, histological analysis, and biomechanical testing. Results The results showed that the TECM scaffold had good biocompatibility for ADSCs. At 2 weeks post-surgery, collagen types I and III and tenomodulin expression were higher, and vascular endothelial growth factor expression was lower in the micro-tissue group than other groups. At 4 and 8 weeks post-surgery, the results of histological analysis and ultrasound findings showed that the repaired tendon tissue was smooth and lustrous, and was arranged regularly and evenly in the micro-tissue group. Gait analysis confirmed that better motor function recovery was noted in micro-tissue group than other groups. In addition, the mechanical properties of the repaired tendon tissue in micro-tissue group were better than other groups. Conclusion Tissue-engineered tendon micro-tissue fabricated by TECM and ADSCs has good biocompatibility and can promote structural and functional repair of tendon in vivo. This composite biomaterial has broad application prospects in tissue engineering.

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Section: Discussionmentioning

confidence: 99%