Advances in the application of computational pathology in diagnosis, immunomicroenvironment recognition, and immunotherapy evaluation of breast cancer: a narrative review

Luo, Jie; Li, Xia; Wei, Kang-Lai; Chen, Gang; Xiong, Dandan

doi:10.1007/s00432-023-05002-8

Cited by 1 publication

(1 citation statement)

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“…Through navigating the intricate landscape of resistance, we present insights into both established and novel strategies to outmaneuver the adaptive nature of tumors [19]. This review encapsulates the critical need for adaptability in treatment approaches, the ongoing quest for data-driven precision in patient-focused care, and the overarching potential of immunotherapy to redefine the future of cancer treatment [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Navigating the Immune Maze: Pioneering Strategies for Unshackling Cancer Immunotherapy Resistance

Yao,

Wang,

2023

Cancers

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Cancer immunotherapy has ushered in a transformative era in oncology, offering unprecedented promise and opportunities. Despite its remarkable breakthroughs, the field continues to grapple with the persistent challenge of treatment resistance. This resistance not only undermines the widespread efficacy of these pioneering treatments, but also underscores the pressing need for further research. Our exploration into the intricate realm of cancer immunotherapy resistance reveals various mechanisms at play, from primary and secondary resistance to the significant impact of genetic and epigenetic factors, as well as the crucial role of the tumor microenvironment (TME). Furthermore, we stress the importance of devising innovative strategies to counteract this resistance, such as employing combination therapies, tailoring immune checkpoints, and implementing real-time monitoring. By championing these state-of-the-art methods, we anticipate a paradigm that blends personalized healthcare with improved treatment options and is firmly committed to patient welfare. Through a comprehensive and multifaceted approach, we strive to tackle the challenges of resistance, aspiring to elevate cancer immunotherapy as a beacon of hope for patients around the world.

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