Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds

Abstract

The current study provides an overview of the synthetic routes, reactivity and privileged biological characteristics of bicyclic heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine cores.

Nanomagnetic macrocyclic Schiff-base–Mn(ii) complex: an efficient heterogeneous catalyst for click approach synthesis of novel β-substitued-1,2,3-triazoles

“…18 Among various heterocyclic molecules, N-containing heterocycles are considered as the main class of drugs. 17,[19][20][21][22][23] In this sense, triazoles compounds, as chemical intermediates, are broadly utilized in numerous industrial formulations including biological and pharmaceutical ones. 24,25 Towards this end, various approaches have been utilized to synthesize 1,2,3triazole moieties.…”

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs

“…Thus, this study has been undertaken as a persistence of our previous programs and studies on highlighting the chemistry of heterocyclic compounds with miscellaneous biological activities and their significance in the fields of medicinal and pharmaceutical chemistry. [52][53][54][55][56][57][58][59] Our program deals with highlighting and exploring the prosperous medicinal chemistry of pyranopyrimidine compounds, particularly pyranoij2,3-d]pyrimidines, in the last five years. The topic of this research is an extension of our previous study that is interesting to highlight the recent methods and progress in the multicomponent synthesis of heterocycleincorporated pyranoij2,3-d]pyrimidine motif under different conditions.…”

Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

“…The prospects of the research were focused on finding novel strategies of suitable conditions, short reaction time, ease of catalyst preparation, efficient catalyst, ease of product purification, accessible reagent, and green protocols. Consequently, based on the above-mentioned findings and in the permanence of our attention on the chemistry of bicyclic systems, 35,36 we focus on highlights in this review, the recent progress in the multicomponent, and multistep synthesis of pyrano[2,3- d ]pyrimidines including the discussion of the diverse approaches, reaction conditions, products yields, the proposed mechanisms for the pyranopyrimidine ring construction, and biological profiles.…”