Advances in the clinical translation of nanotechnology

Scheinberg, David A.; Grimm, Jan; Heller, Daniel A.; Stater, Evan P.; Bradbury, Michelle S.; McDevitt, Michael R.

doi:10.1016/j.copbio.2017.01.002

Cited by 32 publications

(20 citation statements)

References 56 publications

(75 reference statements)

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“…After tumor formation, 50 μCi of 89 Zr-labeled TNP ( 8 = 1 mg/mL, 200 μL), which was prepared using a chelator-free heat-assisted radiolabeling approach 25, 29 , were administered i.v., followed by euthanasia and organ collection 24 h post administration. The radioactivity of the organs was measured with a PerkinElmer Wizard 2 2480 Automatic Gamma Counter (Waltham, MA).…”

Section: Methodsmentioning

confidence: 99%

Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points

Kaittanis¹,

Bolaender²,

Yoo³

et al. 2017

Nano Lett.

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Novel translational approaches based on clinical modular nanoplatforms are needed, in order to treat solid cancers according to their discrete molecular features. In the present study, we show that the clinical nanopharmaceutical Ferumoxytol, which consists of a glucose-based coat surrounding an iron oxide core, could identify molecular characteristics of prostate cancer, corresponding to unique phases of the disease continuum. By affixing a targeting probe for the prostate-specific membrane antigen on its surface, the nanopharmaceutical was able to assess the functional state of the androgen receptor pathway via MRI, guiding therapy and delivering it with the same clinical nanoparticle. In order to simultaneously inhibit oncogenic signaling from key oncogenic pathways of more advanced forms of prostate cancer, a single-agent therapy for early-stage disease to inhibit DNA replication, as well as combination therapy with two drugs co-retained within the nanopharmaceutical’s polymeric coating, were tested, and resulted complete tumor ablation. Recalcitrant and terminal forms of the disease were effectively treated with a nanoparmaceutical delivering a combination that upregulates endoplasmic reticulum stress and inhibits metastasis, thereby showing that this multifunctional nanoplatfom can be used in the clinic for patient stratification, as well as precision treatment based on the individual’s unique disease features.

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Section: Methodsmentioning

confidence: 99%

Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points

Kaittanis¹,

Bolaender²,

Yoo³

et al. 2017

Nano Lett.

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“…Nanomaterials include nanoscale particles that have been leveraged for biological applications such as imaging, gene or drug delivery, and therapeutics. [ 1,2 ] Nanomaterials can offer advantages over biological materials for said applications due to their tunable physicochemical properties that enable the manipulation of nanoparticles with different chemistries to create multiple modalities on a single particle. In particular, single‐walled carbon nanotubes (SWCNTs) have been used as cellular delivery vehicles, fluorescent nanosensors, and implantable diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Covalent Surface Modification Effects on Single‐Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

Chio

Pinals

Murali

et al. 2020

Adv Funct Materials

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Optical nanoscale technologies often implement covalent or noncovalent strategies for the modification of nanoparticles, whereby both functionalizations are leveraged for multimodal applications but can affect the intrinsic fluorescence of nanoparticles. Specifically, single-walled carbon nanotubes (SWCNTs) can enable real-time imaging and cellular delivery; however, the introduction of covalent SWCNT sidewall functionalizations often attenuates SWCNT fluorescence. Recent advances in SWCNT covalent functionalization chemistries preserve the SWCNT's pristine graphitic lattice and intrinsic fluorescence, and here, such covalently functionalized SWCNTs maintain intrinsic fluorescencebased molecular recognition of neurotransmitter and protein analytes. The covalently modified SWCNT nanosensor preserves its fluorescence response towards its analyte for certain nanosensors, presumably dependent on the intermolecular interactions between SWCNTs or the steric hindrance introduced by the covalent functionalization that hinders noncovalent interactions with the SWCNT surface. These SWCNT nanosensors are further functionalized via their covalent handles with a targeting ligand, biotin, to self-assemble on passivated microscopy slides, and these dual-functionalized SWCNT materials are explored for future use in multiplexed sensing and imaging applications.

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“…The 10-year survival rate for Stage IA is 93%, while patients diagnosed at Stage IV have a 10-year survival rate of 10-15% only (16)(17)(18). Moreover, the cost of treating melanoma increases dramatically with later stages of the disease (19)(20)(21). In addition to the clinical and histological examination, many new techniques have been utilized to aid early detection of melanoma.…”

Section: Nanomedicine For Melanoma Detection and Treatmentmentioning

confidence: 99%

“…Nanotechnology has been used in medicine for developing nanometer scale materials, ranging from 1 to 100 nm, having therapeutic and diagnostic purposes (51)(52)(53). Nanomaterials' size range matches cellular organelles, other molecules involved in intracellular events, as signaling pathways, and/or molecules involved in cell to cell communication (16,20). The nanomaterials bio-distribution is dependent on the surface charge, biodegradability, size, their distinct biological properties, and shape (19,(21)(22)(23)(24)(25).…”

Section: Nanomedicine For Melanoma Detection and Treatmentmentioning

confidence: 99%

Nanomedicine in Melanoma: Current Trends and Future Perspectives

El-Kenawy

Constantin

Hassan

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

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Abstract:As cutaneous melanoma is a highly aggressive and drug-resistant cancer, there is intense research focusing on developing new, efficient drugs. Nanomedicine focuses on developing different groups of nanomaterials for both diagnosis and therapy, and this combination of specific diagnosis and therapy is called theranostics. Nanomaterials tailored as delivery vehicles can be nanocapsules, nanorods, nanotubes, nanoshells, and nanocages. All these structures protect the intended drug against degradation and enhance its stability. The development and characterization of polymeric nanoparticles, polymeric micelles, liposomes, nanohydrogel, dendrimers, inorganic nanoparticles, and hybrid nanocarriers are among the delivery vehicles that transport different anticancer agents. Functionalization of nanocarriers with specific molecules, such as antibodies, can generate different smart nanodrugs for application in cancer therapy and/or diagnosis. Nanotherapeutic strategies deal with several shortcomings that comprise of tumor characteristics, biological barriers, biocompatibility, and so on. As nanostructures interact with various host biomolecules, comprehensive in vitro cellular models call for evaluation of physicochemical properties, dose, and time of action of nanomaterials, while in vivo assessments would provide valuable data regarding the level of absorption, tissue/organ distribution, and metabolism. The future perspectives in nanotechnology applied to cancer overcomes the translational barrier from the laboratory to the clinical application to potentially improve conventional theranostic techniques.

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Advances in the clinical translation of nanotechnology

Cited by 32 publications

References 56 publications

Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points

Targetable Clinical Nanoparticles for Precision Cancer Therapy Based on Disease-Specific Molecular Inflection Points

Covalent Surface Modification Effects on Single‐Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

Nanomedicine in Melanoma: Current Trends and Future Perspectives

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