Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System

Mendonça, Monique Culturato Padilha; Kont, Ayse; Aburto, María Rodríguez; Cryan, John F.; O’Driscoll, Caitriona M.

doi:10.1021/acs.molpharmaceut.0c01238

Cited by 43 publications

(21 citation statements)

References 157 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, its clinical utilization has been hindered by the lack of efficient means for its delivery. 138,139 Recently, multifunctional gold nanoparticles (AuNPs) have been studied as non-viral vectors for moving anticancer agents, proteins, peptides and genes. 140 Luan et al used polyethylenimine (PEI) and PEGylated anisamide (a ligand known to target the Sigma receptor) to cap these gold nanoparticles to yield cationic anisamide-targeted PEGylated gold particles.…”

Section: Recent Applications Of Ptx Nanomedicine For the Treatment Of...mentioning

confidence: 99%

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Recent Applications Of Ptx Nanomedicine For the Treatment Of...mentioning

confidence: 99%

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although FANA's are more stable, there needs to be more research on incorporating them within current agricultural practices such as with slow-release clays, chemical penetrants or surfactants similar to slow release fertilizers and pesticides (Ghosh et al, 2018;Hunter and Sinisterra-Hunter, 2018;Rudmin et al, 2020;Vega-Vásquez et al, 2020). Advances in medical applications includes nanoparticle-assisted delivery is rapidly developing a wide variety of molecules (Hammond et al, 2021;Mendonça et al, 2021). These novel materials may provide greater utility of biopesticide products in agriculture (Vega-Vásquez et al, 2020), aided by bioengineering and novel production methods to reduce costs or to add unique traits (Hochella et al, 2019), providing benefits across the environmental sciences (Lespes et al, 2020;Li et al, 2020;Slaveykova et al, 2020).…”

Section: Future Directionsmentioning

confidence: 99%

Improving Suppression of Hemipteran Vectors and Bacterial Pathogens of Citrus and Solanaceous Plants: Advances in Antisense Oligonucleotides (FANA)

Hunter

Cooper²,

Sandoval-Mojica

et al. 2021

Front. Agron.

View full text Add to dashboard Cite

We report on the development, evaluation, and efficient delivery of antisense oligonucleotide FANA (2′-deoxy-2′-fluoro-arabinonucleotide) RNA-targeting technology into citrus trees and potato plants for management of bacterial pathogens and arthropod pests. The FANA ASO technology is a single nucleotide strand of 20–24 nt in length that incorporates 2′F- chemically modifications of nucleotides, along with a phosphorothioate backbone and modified flanking nucleotides, in their structure called “gapmers,” produced by AUM LifeTech., Inc. These unique modified structures of FANA “triggers” enables gymnotic activity that self-delivers into cells, moving systemically in treated plants and insects, with significant suppression of their RNA targets. Reported is the FANA suppression of two plant-infecting bacterium Candidatus Liberibacter asiaticus, CLas (in citrus trees), and C. Liberibacter solanacearum, CLso (in potato and tomato). The CLas pathogen is associated with huanglongbing (a.k.a. Citrus Greening Disease), which causes severe loss of citrus trees, threatening global citrus production. The CLas bacterium is transmitted during feeding by the Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae). CLso causes Zebra-Chip disease in potato and is transmitted by the potato psyllid, Bactericera cockerelli (Hemiptera: Triozidae). Infected citrus trees or potato plants were treated with aqueous FANA solutions applied as a soil drench, root-infusion, topical spray, tree trunk injection or by absorption into cuttings, detached leaves, and leaf disks. Plants showed significant reduction of each pathogen or symptom development in response to FANA treatments. Similarly, ingestion of FANA solutions designed specifically to CLas by insects via artificial diets produced significant titer reductions in infected citrus psyllid adults that resulted in reduction of CLas transmission. The unique properties of FANA ASO solves many of the problems of stability, cell entry, and binding affinity that plagues exogenous RNAi strategies. Breakthroughs in production methods are reducing costs enabling these ASO to expand beyond medical applications into agricultural treatments. Thus, FANA ASO may provide viable treatments in the response to crop pandemics, like huanglongbing in citrus that threatens global food production.

show abstract

“…Small interfering RNA (siRNA) showed great potential in advanced therapeutics because of its highly sequential ability for silencing genes [115]. One of the most common causes of death in women is cervical cancer [116].…”

Section: Small Interfering Rna-selenium Npsmentioning

confidence: 99%

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

et al. 2021

View full text Add to dashboard Cite

In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on the other hand, have limitations that make early detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors have revolutionized the era of cancer diagnosis and treatment for targeted action via attaching specified and biocompatible ligands to target the tissues, which are highly over-expressed in certain types of cancers. Advancements in multi-functionalized NPs can be achieved via modifying molecular genetics to develop personalized and targeted treatments based on RNA interference. Modification in RNA therapies utilized small RNA subunits in the form of small interfering RNAs (siRNA) for overexpressing the specific genes of, most commonly, breast, colon, gastric, cervical, and hepatocellular cancer. RNA-conjugated nanomaterials appear to be the gold standard for preventing various malignant tumors through focused diagnosis and delivering to a specific tissue, resulting in cancer cells going into programmed death. The latest advances in RNA nanotechnology applications for cancer diagnosis and treatment are summarized in this review.

show abstract

Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System

Cited by 43 publications

References 157 publications

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Improving Suppression of Hemipteran Vectors and Bacterial Pathogens of Citrus and Solanaceous Plants: Advances in Antisense Oligonucleotides (FANA)

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

Contact Info

Product

Resources

About