Advances in the Determination of Nonprotein Amino Acids in Foods and Biological Samples by Capillary Electrophoresis

Pérez-Míguez, Raquel; Salido-Fortuna, Sandra; Castro-Puyana, María; Marina, Marı́a Luisa

doi:10.1080/10408347.2018.1546113

Cited by 14 publications

(11 citation statements)

References 62 publications

(110 reference statements)

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“…In this regard, the latest advances in the development of CE analytical methods for AAs analysis in foods and biological samples, mainly focused on nonprotein AAs, have been recently reviewed by Perez‐Miguez et al. [23].…”

Section: Amino Acids Bas Heterocyclic Amines and Other Hazardous Aminesmentioning

confidence: 99%

“…An interesting alternative to UV detection approaches is MS that presents higher sensitivity and selectivity than other systems, providing structural information [23]. Thus, a CE system coupled to a TOF MS detector was successfully applied by Izu et al.…”

Section: Amino Acids Bas Heterocyclic Amines and Other Hazardous Aminesmentioning

confidence: 99%

“…The application of CE to the analysis of lipids [13], macrolides [16], mycotoxins [17], allergenic proteins in dairy products [19], colorants [20], veterinary drug residues [21], water-soluble vitamins [22], nonprotein amino acids (AA) [23] in food matrices has also been recently reviewed.…”

Section: Introductionmentioning

confidence: 99%

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Capillary electromigration methods for food analysis and Foodomics: Advances and applications in the period February 2019–February 2021

et al. 2021

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This work presents a revision of the main applications of capillary electromigration methods in food analysis and Foodomics. Articles that were published during the period February 2019‐February 2021 are included. The work shows the multiple CE methods that have been developed and applied to analyze different types of molecules in foods. Namely, CE methods have been applied to analyze amino acids, biogenic amines, carbohydrates, chiral compounds, contaminants, DNAs, food additives, heterocyclic amines, lipids, secondary metabolites, peptides, pesticides, phenols, pigments, polyphenols, proteins, residues, toxins, vitamins, small organic and inorganic compounds, as well as other minor compounds. The last results on the use of CE for monitoring food interactions and food processing, including recent microchips developments and new applications of CE in Foodomics, are discussed too. The new procedures of CE to investigate food quality and safety, nutritional value, storage and bioactivity are also included in the present review work.

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Section: Amino Acids Bas Heterocyclic Amines and Other Hazardous Aminesmentioning

confidence: 99%

Section: Amino Acids Bas Heterocyclic Amines and Other Hazardous Aminesmentioning

confidence: 99%

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Capillary electromigration methods for food analysis and Foodomics: Advances and applications in the period February 2019–February 2021

et al. 2021

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“…From the listed separation techniques, our review is focused on the determination of AAs using CE. High application potential of CE for analysis of AAs is illustrated by variety of reviews covering periodically the published articles in this area [3‐7]. In addition to high separation efficiency, CE offers benefits, such as the low consumption of samples, BGE, and washing solutions, and consequently has a low production of waste.…”

Section: Introductionmentioning

confidence: 99%

Homocyclic o‐dicarboxaldehydes: Derivatization reagents for sensitive analysis of amino acids and related compounds by capillary and microchip electrophoresis

Celá

Glatz

2020

Electrophoresis

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Amino acids are essential compounds for living organisms, and their determination in biological fluids is crucial for the clinical analysis and diagnosis of many diseases. However, the detection of most amino acids is hindered by the lack of a strong chromophore/fluorophore or electrochemically active group in their chemical structures. The highly sensitive determination of amino acids often requires derivatization. Capillary electrophoresis is a separation technique with excellent characteristics for the analysis of amino acids in biological fluids. Moreover, it offers the possibility of precapillary, on‐capillary, or postcapillary derivatization. Each derivatization approach has specific demands in terms of the chemistry involved in the derivatization, which is discussed in this review. The family of homocyclic o‐dicarboxaldehyde compounds, namely o‐phthalaldehyde, naphthalene‐2,3‐dicarboxaldehyde, and anthracene‐2,3‐dicarboxaldehyde, are powerful derivatization reagents for the determination of amino acids and related compounds. In the presence of suitable nucleophiles they react with the primary amino group to form both fluorescent and electroactive derivatives. Moreover, the reaction rate enables all of the derivatization approaches mentioned above. This review focuses on articles that deal with using these reagents for the derivatization of amino acids and related compounds for ultraviolet‐visible spectrometry, fluorescence, or electrochemical detection. Applications in capillary and microchip electrophoresis are summarized and discussed.

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“…16 In the latter, the vast majority of studies regards to proteomic analysis, 12,15 but also includes other applications, such as metabolomics, 17,18 and genomics. 19 In this context, CE-MS techniques are employed in the analysis of biomarkers of body fluids related to diseases, 20 analysis of quality markers in foods, 21 studies of affinity interactions, 22 among many others.…”

Section: Introductionmentioning

confidence: 99%

How Coupled are Mass Spectrometry and Capillary Electrophoresis?

Ceribeli,

de Arruda,

Costa

2019

Preprint

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The understanding of how science works can contribute to making scientific development more effective. In this paper, we report an analysis of the organization and interconnection between two important issues in chemistry, namely mass spectrometry (MS) and capillary electrophoresis (CE). For that purpose, we employed science of science techniques based on complex networks. More specifically, we considered a citation network in which the nodes and connections represent papers and citations, respectively. Interesting results were found, including a good separation between some clusters of articles devoted to instrumentation techniques and applications. However, the papers that describe CE-MS did not lead to a well-defined cluster. In order to better understand the organization of the citation network, we considered a multi-scale analysis, in which we used the information regarding sub-clusters. Firstly, we analyzed the sub-cluster of the first article devoted to the coupling between CE and MS, which was found to be a good representation of its sub-cluster. The second analysis was about the sub-cluster of a seminal paper known to be the first that dealt with proteins by using CE-MS. By considering the proposed methodologies, our paper paves the way for researchers working with both techniques, since it elucidates the knowledge organization and can therefore lead to better literature reviews.

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Advances in the Determination of Nonprotein Amino Acids in Foods and Biological Samples by Capillary Electrophoresis

Cited by 14 publications

References 62 publications

Capillary electromigration methods for food analysis and Foodomics: Advances and applications in the period February 2019–February 2021

Capillary electromigration methods for food analysis and Foodomics: Advances and applications in the period February 2019–February 2021

Homocyclic o‐dicarboxaldehydes: Derivatization reagents for sensitive analysis of amino acids and related compounds by capillary and microchip electrophoresis

How Coupled are Mass Spectrometry and Capillary Electrophoresis?

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