Advances in the Development of Biodegradable Polymeric Materials for Biomedical Applications

Patra, Sukanya; Singh, Monika; Pareek, Divya; Wasnik, Kirti; Gupta, Prem Shankar; Paik, Pradip

doi:10.1016/b978-0-12-820352-1.00129-2

Cited by 6 publications

(8 citation statements)

References 314 publications

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Section: Biosensing and Bioelectronicsmentioning

confidence: 99%

Proto-Neurons from Abiotic Polypeptides

Mougkogiannis,

Adamatzky

2024

Encyclopedia

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To understand the origins of life, we must first gain a grasp of the unresolved emergence of the first informational polymers and cell-like assemblies that developed into living systems. Heating amino acid mixtures to their boiling point produces thermal proteins that self-assemble into membrane-bound protocells, offering a compelling abiogenic route for forming polypeptides. Recent research has revealed the presence of electrical excitability and signal processing capacities in proteinoids, indicating the possibility of primitive cognitive functions and problem-solving capabilities. This review examines the characteristics exhibited by proteinoids, including electrical activity and self-assembly properties, exploring the possible roles of such polypeptides under prebiotic conditions in the emergence of early biomolecular complexity. Experiments showcasing the possibility of unconventional computing with proteinoids as well as modelling proteinoid assemblies into synthetic proto-brains are given. Proteinoids’ robust abiogenic production, biomimetic features, and computational capability shed light on potential phases in the evolution of polypeptides and primitive life from the primordial environment.

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Section: Biosensing and Bioelectronicsmentioning

confidence: 99%

Proto-Neurons from Abiotic Polypeptides

Mougkogiannis,

Adamatzky

2024

Encyclopedia

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“…Ongoing research is aimed at unravelling the mechanisms underlying proteinoids' sensing capacities in order to build responsive materials. Using proteinoids for applications ranging from real-time monitoring to biocomputing necessitates an interdisciplinary approach encompassing chemistry, biology, physics, and engineering [207]. Proteinoids, due to their adjustable design, emergent dynamics, and biocompatibility, offer a wide range of options for biosensing and bioelectronic technology.…”

Section: Biosensing and Bioelectronicsmentioning

confidence: 99%

“…Applications of proteinoid-based hydrogels[207]. Aspartic acid, Glutamic acid Delivery of antisteroidal non-inflammatory drugs, cell culture, tissue engineering…”

mentioning

confidence: 99%

Proto–Neurons from Abiotic Polypeptides

---,

Adamatzky

2023

Preprint

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Understanding the origins of life involves dealing with the unresolved question of how the first informational polymers and cell-like structures emerged from prebiotic chemistry. The formation of thermal proteinoids through the heating of mixtures of amino acids, leading to the spontaneous formation of protocells enclosed by membranes, presents a compelling model for the synthesis of polypeptides in an abiogenic context. Recent research has revealed the presence of electrical excitability and signal processing capacities in proteinoids, indicating the possibility of primitive cognitive functions and problem-solving capabilities. The present study provides a comprehensive examination of the features shown by heat proteinoids and their potential significance in the context of the artificial formation of polypeptides during the early stages of Earth’s development. Experiments showcasing the possibility for unconventional computing with proteinoids as well as modelling proteinoid assemblies into synthetic proto-brains are given. Proteinoids’ robust abiogenic production, biomimetic features, and computational capability shed light on potential phases in the evolution of polypeptides and primitive life from the primordial environment.

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“…The thickness of the film varies depending on the nutrients and breeding time [14]. Kombucha cellulose shows high biocompatibility due to its enhanced cell-matrix interactions, cell signalling pathways and ability to maintain cellular homeostasis [15]. In our previous studies, we have demonstrated that Kombucha cellulose mats show rich dynamics of electrical activity, represented by spikes of electrical potential.…”

Section: Introductionmentioning

confidence: 99%

Functionalising the electrical properties of Kombucha zoogleal mats for biosensing applications

Nikolaidou,

Chiolerio,

Dehshibi

et al. 2024

Preprint

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Kombucha is a type of tea that is fermented using yeast and bacteria. During this process, a film made of cellulose is produced. This film has unique properties such as biodegradability, flexibility, shape conformability, and ability to self-grow, as well as be produced across customised scales. In our previous studies, we demonstrated that Kombucha mats exhibit electrical activity represented by spikes of electrical potential. We propose using microbial fermentation as a method for in situ functionalisation to modulate the electroactive nature of Kombucha cellulose mats, where graphene and zeolite were used for the functionalisation. We subjected the pure and functionalised Kombucha mats to mechanical stimulation by applying different weights and geometries. Our experiments demonstrated that Kombucha mats functionalised with graphene and zeolite exhibit memfractive properties and respond to load by producing distinctive spiking patterns. Our findings present incredible opportunities for the in situ development of functionalised hybrid materials with sensing, computing, and memory capabilities. These materials can self-assemble and self-grow after fusing their living and synthetic components. This study contributes to an emergent area of research on bioelectronic sensing and hybrid living materials, opening up exciting opportunities for use in smart wearables, diagnostics, health monitoring and energy harvesting applications.

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Advances in the Development of Biodegradable Polymeric Materials for Biomedical Applications

Cited by 6 publications

References 314 publications

Proto-Neurons from Abiotic Polypeptides

Proto-Neurons from Abiotic Polypeptides

Proto–Neurons from Abiotic Polypeptides

Functionalising the electrical properties of Kombucha zoogleal mats for biosensing applications

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