Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease

Sánchez, Juan D.; Alcántara, Andrés R.; González, Juan F.; Sánchez-Montero, José María

doi:10.1080/17460441.2023.2264766

Expert Opinion on Drug Discovery

2023

DOI: 10.1080/17460441.2023.2264766

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Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease

Juan D. Sánchez,

Andrés R. Alcántara,

Juan F. González

et al.

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Cited by 4 publications

References 108 publications

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Recent Progresses in Development of Heterocyclic Compounds For Epilepsy Treatment: Key Research Highlights from 2019–2024

Singh,

Nisa,

Mavi

et al. 2024

Chemistry & Biodiversity

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Epilepsy which is a chronic neurological disorder is characterized by recurrent seizure poses a significant challenge to healthcare professionals worldwide. Most of antiepileptic drugs have serious side effects that might affect the quality of life such as fatigue, dizziness, weight gain and cognitive impairments. In this context, the search for more effective and potential antiepileptic drug candidate has led to a growing interest in the field of synthesis of heterocyclic compounds. This review will focus on the utilization of heterocyclic moieties including imidazole, indole, thiazole, triazine, quinazoline and oxazole which show remarkable anticonvulsant properties. Furthermore, the exploration of various methodologies for the synthesis of heterocyclic anticonvulsant drugs such as green methodologies and microwave assisted protocols have contributed to the development of environment friendly, more efficient and potential approaches. The review will distinguish from previous ones by specifically focusing on innovative synthetic methodologies, including greener methodologies and micro‐assisted techniques, that contribute to eco‐friendly and environment benign approaches during 2019–2024. In addition to this, the review will focus on the Structure Activity Relationship (SAR) studies of heterocyclic compounds in order to offer insight into the design of next generation antiepileptic drugs with improved efficacy and reduced side effects.

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Recent Progresses in Development of Heterocyclic Compounds For Epilepsy Treatment: Key Research Highlights from 2019–2024

Singh,

Nisa,

Mavi

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Integrating Multi-omics Data for Alzheimer’s Disease to Explore Its Biomarkers Via the Hypergraph-Regularized Joint Deep Semi-Non-Negative Matrix Factorization Algorithm

Tu,

Zhou,

Kong

2024

J Mol Neurosci

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Predicting the effects of drugs and unveiling their mechanisms of action using an interpretable pharmacodynamic mechanism knowledge graph (IPM-KG)

Tanaka,

Katayama,

Imai

2025

Computers in Biology and Medicine

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Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease

Cited by 4 publications

References 108 publications

Recent Progresses in Development of Heterocyclic Compounds For Epilepsy Treatment: Key Research Highlights from 2019–2024

Recent Progresses in Development of Heterocyclic Compounds For Epilepsy Treatment: Key Research Highlights from 2019–2024

Integrating Multi-omics Data for Alzheimer’s Disease to Explore Its Biomarkers Via the Hypergraph-Regularized Joint Deep Semi-Non-Negative Matrix Factorization Algorithm

Predicting the effects of drugs and unveiling their mechanisms of action using an interpretable pharmacodynamic mechanism knowledge graph (IPM-KG)

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