Advances in the extracellular signal‐regulated kinase signaling pathway in silkworms, Bombyx mori (Lepidoptera)

Abstract

Signaling pathways regulate the transmission of signals during organism growth and development, promoting the smooth and accurate completion of numerous physiological and biochemical reactions. The extracellular signal‐regulated kinase (ERK) signaling pathway is an essential pathway involved in regulating various physiological processes, such as cell proliferation, differentiation, adhesion, migration, and more. This pathway also contributes to several important physiological processes in silkworms, including protein synthesis, reproduction, and immune defense against pathogens. Organizing related studies on the ERK signaling pathway in silkworms can provide a better understanding of its mechanism in Lepidopterans and develop a theoretical foundation for improving cocoon production and new strategies for pest biological control.

The Long-Acting Serine Protease Inhibitor mPEG-SPA-MDSPI16 Alleviates LPS-Induced Acute Lung Injury

“…We hypothesized that mPEG-SPA-MDSPI16 plays an inhibitory role in the preactivation of the NF-κB signaling pathway. The MAPK pathway consists of three classical signal transduction pathways: the c-Jun N-terminal kinase (JNK) signaling pathway, the p38 MAPK signaling pathway, and the extracellular signal-regulated kinase (ERK) signaling pathway [24][25][26]. The activated MAPK pathway is involved in various activities, such as the stress response, signal transduction, apoptosis, and the development of inflammatory disease, by regulating the activity of various transcription factors [27].…”