Advances in the Genetics of Anti-Glomerular Basement Membrane Disease

Zhou, Xu‐jie; Lv, Jicheng; Zhao, Minghui; Zhang, Hong

doi:10.1159/000321324

Cited by 22 publications

(12 citation statements)

References 122 publications

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“…Anti-GBM disease shows an incidence of 0.5-1 case/million people per year [50] . It has been proposed that anti-GBM disease could be triggered over genetically predisposed patients (HLA-DRB1*1501 allele and genes of the FCGR and KLK families [51] ) by environmental or cellular/humoral immunity factors. These auto-antibodies attack GBM disturbing its intrinsic structure, explaining the almost always present haematuria, with nephritic syndrome and crescentic glomerulonephritis.…”

Section: Primary Gbm Disordersmentioning

confidence: 99%

Pathogenesis of glomerular haematuria

Yuste

Gutiérrez

Sevillano

et al. 2015

WJN

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Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells (RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings.

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Section: Primary Gbm Disordersmentioning

confidence: 99%

Pathogenesis of glomerular haematuria

Yuste

Gutiérrez

Sevillano

et al. 2015

WJN

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“…[1] It is responsible for 10-20% of rapidly progressive renal failure. [2] The renal biopsy shows crescentic glomerulonephritis (CrGN) >50% glomeruli with crescents) in more than 80% of patients.…”

Section: Introductionmentioning

confidence: 99%

Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature

Gupta¹,

Agrawal²,

Kaul³

et al. 2016

Indian J Nephrol

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Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune disease that most commonly presents as rapidly progressive glomerulonephritis with or without pulmonary involvement. It is characterized by the presence of antibodies directed to antigenic targets within glomerular and alveolar basement membranes. This study was performed to evaluate the clinicopathological features and outcome in anti-GBM crescentic glomerulonephritis (CrGN) at a tertiary care center in North India over a period of 9 years (January 2004 to December 2012). A diagnosis of anti-GBM CrGN was made in the presence of >50% crescents, linear deposits of IgG along GBM, and raised serum anti-GBM antibody titer. Of 215 cases of CrGN diagnosed during this period, 11 had anti-GBM CrGN. Anti-GBM CrGN was found at all ages but was most common in the third to fifth decade with no gender predilection (mean age 48 +/- 15 years, 13–67 years). Patients presented with a mean serum creatinine of 10.2 +/- 5.3 mg/dl and sub-nephrotic proteinuria. Pulmonary involvement was present in two patients. Myeloperoxidase-antineutrophil cytoplasmic antibody was positive in two (2/11) elderly patients. Follow-up was available in four patients for a range of 30-270 (mean 99.5 ± 114.5) days, two remained dialysis dependent while two died due to uremia and sepsis. Our findings show that anti-GBM disease is a rare cause of CrGN in India, accounting for only 5% of patients. It usually presents as a renal-limited disease and is associated with a poor renal outcome.

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“…We also reported on the overlap between several autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, ANCA-associated small vasculitis, and anti-glomerular basement membrane disease (16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Thus, we hypothesized that refinement of GWAS data or identification of IgAN susceptibility genes could be underpinned by investigation of the genetic variants reported to be associated with other immune-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Association of Systemic Lupus Erythematosus Susceptibility Genes with IgA Nephropathy in a Chinese Cohort

Zhou

Cheng

Zhu

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives One hypothesis states that IgA nephropathy (IgAN) is a syndrome with an autoimmune component. Recent studies strongly support the notion of shared genetics between immune-related diseases. This study investigated single-nucleotide polymorphisms (SNPs) reported to be associated with systemic lupus erythematosus (SLE) in a Chinese cohort of patients with IgAN and in controls.Design, setting, participants, & measurements This study investigated whether SNP markers that had been reported to be associated with SLE were also associated with IgAN in a Chinese population.

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Advances in the Genetics of Anti-Glomerular Basement Membrane Disease

Cited by 22 publications

References 122 publications

Pathogenesis of glomerular haematuria

Pathogenesis of glomerular haematuria

Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature

Association of Systemic Lupus Erythematosus Susceptibility Genes with IgA Nephropathy in a Chinese Cohort

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