1997
DOI: 10.1002/(sici)1097-0029(19970515)37:4<245::aid-jemt2>3.0.co;2-k
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Advances in the microscopy of osteoarthritis

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Cited by 27 publications
(12 citation statements)
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References 156 publications
(106 reference statements)
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“…The first morphological alteration of the cartilage in the OA is the swelling of the superficial and middle zones of the extracellular matrix . This expands the cartilage matrix swelling, stretching the fibrous mesh of the surface region, resulting in the softening of the cartilage.…”
Section: Discussionmentioning
confidence: 99%
“…The first morphological alteration of the cartilage in the OA is the swelling of the superficial and middle zones of the extracellular matrix . This expands the cartilage matrix swelling, stretching the fibrous mesh of the surface region, resulting in the softening of the cartilage.…”
Section: Discussionmentioning
confidence: 99%
“…In early OA lesions within the joint surface, the chondrocytes distant from these lesions are capable of a coordinated response, leading to a distinct spatial reorganization introducing a novel spatial pattern (7). In contrast, chondrocytes within or adjacent to OA lesions undergo clustering that is typical of OA (8), in which unorganized aggregation results in the abandonment of typical spatial characteristics. During OA progression, chondrocytes may lose their sense of spatial order and their remodeling capability.…”
mentioning
confidence: 99%
“…A debate persists whether the disease process originates from the cartilage or the subchondral bone. However, it is commonly thought that OA develops in the majority of the patients at the level of chondrocytes62 and specifically at the articular surface63 64 where proliferative chondrocyte clones characteristically form at the margins of fibrillation 27 65. These chondrocyte clones are a histological hallmark of OA termed cell clusters.…”
Section: Reviewmentioning
confidence: 99%
“…Chondrocytes within or adjacent to OA lesions undergo an OA-typical clustering,65 in which unorganised aggregation results in the abandonment of typical spatial characteristics. We investigated whether such processes may be used to diagnose early OA events38 before manifest OA results in tissue destruction and clinical symptoms.…”
Section: Reviewmentioning
confidence: 99%
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