Advances in the relationship between Kruppel-like factor 15 and cardiovascular disease research

Abstract

Kruppel-like factor 15 (KLF15) is a subtype of the Kruppellike family of transcription factors (KLFs). KLFs have three high-fidelity zinc fingers at the carboxyl terminus that enable them to regulate the biological processes of proliferation, differentiation, cellular development, and apoptosis. KLF15 is highly expressed in the kidney, pancreas, and cardiac and skeletal muscle, and plays an essential role in the development and occurrence of multiple system diseases. In this paper, we underscored the important relationship between KLF15 and cardiovascular diseases such as atherosclerosis, heart failure, arrhythmia, aortic lesions, etc. On this basis, we identified KLF15 as a potential therapeutic target for the treatment of cardiovascular disease.

Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model

“…Although the pathogeneses of atherosclerosis and DVT are different, endothelial cells are important for both atherosclerosis and DVT. Disruption of the endothelium and the release of plaque constituents into the lumen of the blood vessel can trigger arterial thrombosis (13,14). Abnormal blood flow, altered properties of the blood itself and changes in the endothelium can trigger venous thrombosis.…”