Advances in the research of celery, an important Apiaceae vegetable crop

Li, Mengyao; Hou, Xilin; Wang, Zhen; Tan, Guo-Fei; Xu, Zhihong; Xiong, Ai‐Sheng

doi:10.1080/07388551.2017.1312275

Cited by 127 publications

(70 citation statements)

References 97 publications

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“…With the continuous development of sequencing technology, whole-genome sequencing has been carried out in increasing numbers of species, providing a great deal of biological information for genome mapping, functional gene mining and molecular breeding. Celery is normally classified as a cool-season vegetable and widely consumed around the world, and the cultivation history of celery is longer than 2000 years 2,3 . To understand the genetic system and evolution of Apiaceae, we sequenced the genome of celery, which offers new insights and provides resources for molecular breeding.…”

Section: Discussionmentioning

confidence: 99%

“…Apigenin is one of the most important flavonoid compounds and exhibits a variety of biological activities and pharmacological effects 3 . Compared with other plants, celery has a higher content of apigenin 6,8 .…”

Section: Apigenin Biosynthesis Pathway In Celerymentioning

confidence: 99%

“…1b). In addition to containing common nutrients such as vitamins, proteins and carbohydrates, celery contains flavonoids, carotenoids, terpenoids, and unsaturated fatty acids that exhibit biological activity and physiological functions in human beings [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

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The genome sequence of celery (Apium graveolens L.), an important leaf vegetable crop rich in apigenin in the Apiaceae family

Li¹,

Feng²,

Hou³

et al. 2020

Hortic Res

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Celery (Apium graveolens L.) is a vegetable crop in the Apiaceae family that is widely cultivated and consumed because it contains necessary nutrients and multiple biologically active ingredients, such as apigenin and terpenoids. Here, we report the genome sequence of celery based on the use of HiSeq 2000 sequencing technology to obtain 600.8 Gb of data, achieving~189-fold genome coverage, from 68 sequencing libraries with different insert sizes ranging from 180 bp to 10 kb in length. The assembled genome has a total sequence length of 2.21 Gb and consists of 34,277 predicted genes. Repetitive DNA sequences represent 68.88% of the genome sequences, and LTR retrotransposons are the main components of the repetitive sequences. Evolutionary analysis showed that a recent whole-genome duplication event may have occurred in celery, which could have contributed to its large genome size. The genome sequence of celery allowed us to identify agronomically important genes involved in disease resistance, flavonoid biosynthesis, terpenoid metabolism, and other important cellular processes. The comparative analysis of apigenin biosynthesis genes among species might explain the high apigenin content of celery. The whole-genome sequences of celery have been deposited at CeleryDB (http://apiaceae.njau.edu.cn/celerydb). The availability of the celery genome data advances our knowledge of the genetic evolution of celery and will contribute to further biological research and breeding in celery as well as other Apiaceae plants.

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Section: Discussionmentioning

confidence: 99%

Section: Apigenin Biosynthesis Pathway In Celerymentioning

confidence: 99%

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The genome sequence of celery (Apium graveolens L.), an important leaf vegetable crop rich in apigenin in the Apiaceae family

Li¹,

Feng²,

Hou³

et al. 2020

Hortic Res

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“…Celery ( Apium graveolens ) is a biennial plant in the family of Apiaceae, which originated from the Mediterranean basin and the Middle East (Li et al , ). Celery is cultivated worldwide and distinguished as a healthy food for its low energy density and bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Comparative proteomic analysis provides novel insights into chlorophyll biosynthesis in celery under temperature stress

Huang

et al. 2017

Physiologia Plantarum

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Chlorophyll (Chl) is essential for light harvesting and energy transduction in photosynthesis. A proper amount of Chl within plant cells is important to celery (Apium graveolens) yield and quality. Temperature stress is an influential abiotic stress affecting Chl biosynthesis and plant growth. There are limited proteomic studies regarding Chl accumulation under temperature stress in celery leaves. Here, the proteins from celery leaves under different temperature treatments (4, 25 and 38°C) were analyzed using a proteomic approach. There were 71 proteins identified through MALDI-TOF-TOF analysis. The relative abundance of proteins involved in carbohydrate and energy metabolism, protein metabolism, amino acid metabolism, antioxidant and polyamine biosynthesis were enhanced under cold stress. These temperature stress-responsive proteins may establish a new homeostasis to enhance temperature tolerance. Magnesium chelatase (Mg-chelatase) and glutamate-1-semialdehyde aminotransferase (GSAT), related to Chl biosynthesis, showed increased abundances under cold stress. Meanwhile, the Chl contents were decreased in heat- and cold-stressed celery leaves. The inhibition of Chl biosynthesis may be due to the downregulated mRNA levels of 15 genes involved in Chl biosynthesis. The study will expand our knowledge on Chl biosynthesis and the temperature tolerance mechanisms in celery leaves.

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“…After determining the pharmacokinetic properties of a drug,we needed to nd the target genes for drug action.Many articles had shown that compounds extracted from plants were inextricably linked to genes or proteins [32][33][34].To this end,we used CTD to predict 28 genes online (Table 2). Since 6 genes had been reported in our previous research,a total of 34 target genes were in our study.To further explored the function of these 34 genes,we used the GeneMANIA online tool to prove their co-expression,physical communication,co-localization and other functional information (Fig.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

yongan¹,

Yu²,

Li³

et al. 2020

Preprint

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In the synthesis of chemical drugs used to treat various cancers and tumors,more and more scientists are now focusing on the development of natural extracts.Paeoniflorin,as an important compounds of the total glucosides of peony,,had therapeutic effects on a variety of cancers in vivo and in vitro experiments.The purpose of this study was to use biological information analysis to reveal the basic mechanism and potential molecular mechanism of paeoniflorin treatment.We evaluated the efficacy of paeoniflorin through Traditional Chinese Medicine Systems Pharmacology Database(TCMSP).The potential targets of paeoniflorin were identified and summarized by Comparative Toxicogenomics Database (CTD),and GeneMANIA protein interaction analysis was performed online.Also.We used WebGestalt for Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis and functional annotation.Finally,cytoscape was used to construct the paeoniflorin-target-pathway network to predict the results.

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Advances in the research of celery, an important Apiaceae vegetable crop

Cited by 127 publications

References 97 publications

The genome sequence of celery (Apium graveolens L.), an important leaf vegetable crop rich in apigenin in the Apiaceae family

The genome sequence of celery (Apium graveolens L.), an important leaf vegetable crop rich in apigenin in the Apiaceae family

Comparative proteomic analysis provides novel insights into chlorophyll biosynthesis in celery under temperature stress

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

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