Advances in the roles of glycyrrhizic acid in cancer therapy

Zhang, Yuqian; Sheng, Zhaohan; Xiao, Jing; Li, Yang; Huang, Jie; Jia, Jinjing; Zeng, Xiansi; Li, Li

doi:10.3389/fphar.2023.1265172

Cited by 13 publications

(4 citation statements)

References 119 publications

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“…Glycyrrhizic acid is the main active component of TCM Glycyrrhiza uralensis Fisch . Previous studies had shown that glycyrrhizic acid had a wide range of pharmacological effects, such as anti-oxidation, anti-inflammation, anti-viral, anti-cancer, and so on ( Wang and Du, 2016 ; Sun et al, 2019 ; Asseri et al, 2022 ; Zhang Y. et al, 2023 ). In addition, many pieces of evidence had confirmed that glycyrrhizic acid could have certain improvement effects on diabetes and its related complications.…”

Section: Active Compounds From Chinese Herbs Relieve Diabetic Vasculo...mentioning

confidence: 99%

Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

Gao,

Zhang,

Zhang

et al. 2024

Front. Pharmacol.

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Due to its high prevalence, poor prognosis, and heavy burden on healthcare costs, diabetic vascular complications have become a significant public health issue. Currently, the molecular and pathophysiological mechanisms underlying diabetes-induced vascular complications remain incompletely understood. Autophagy, a highly conserved process of lysosomal degradation, maintains intracellular homeostasis and energy balance via removing protein aggregates, damaged organelles, and exogenous pathogens. Increasing evidence suggests that dysregulated autophagy may contribute to vascular abnormalities in various types of blood vessels, including both microvessels and large vessels, under diabetic conditions. Traditional Chinese medicine (TCM) possesses the characteristics of “multiple components, multiple targets and multiple pathways,” and its safety has been demonstrated, particularly with minimal toxicity in liver and kidney. Thus, TCM has gained increasing attention from researchers. Moreover, recent studies have indicated that Chinese herbal medicine and its active compounds can improve vascular damage in diabetes by regulating autophagy. Based on this background, this review summarizes the classification, occurrence process, and related molecular mechanisms of autophagy, with a focus on discussing the role of autophagy in diabetic vascular damage and the protective effects of TCM and its active compounds through the regulation of autophagy in diabetes. Moreover, we systematically elucidate the autophagic mechanisms by which TCM formulations, individual herbal extracts, and active compounds regulate diabetic vascular damage, thereby providing new candidate drugs for clinical treatment of vascular complications in diabetes. Therefore, further exploration of TCM and its active compounds with autophagy-regulating effects holds significant research value for achieving targeted therapeutic approaches for diabetic vascular complications.

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Section: Active Compounds From Chinese Herbs Relieve Diabetic Vasculo...mentioning

confidence: 99%

Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

Gao,

Zhang,

Zhang

et al. 2024

Front. Pharmacol.

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“…In fact, Gly has been shown in preclinical models to inhibit the onset and development of different types of cancer such as cervical, endometrial, colon, gastric, leukaemia, glioblastoma, lung, liver and melanoma. At the same time, it also has a synergistic action with different chemotherapeutics and is useful in reducing the adverse effects of chemotherapy, including hepatotoxicity, nephrotoxicity, genotoxicity, neurotoxicity and pulmonary toxicity [3,5,8,25,26].…”

Section: Anticancer Activity Of Glycyrrhizinic Acidmentioning

confidence: 99%

“…Both glycyrrhizinic acid and glycyrrhetinic acid have shown similar antiviral and anticancer physiological properties [3,4]. Intravenous administration of Gly has also been evaluated, although toxicity is higher than through oral administration [5]. This makes both local and oral administration of Gly potentially useful for the treatment or prevention of viral infections or cancer and may be especially useful in problems resulting from HPV infection (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus

Bravo,

Serrano,

Duque

et al. 2023

JPM

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Human papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV oncogenesis is due to the ability of the viral oncoproteins E6 and E7 to alter the control mechanisms for the growth and proliferation of host cell. Therefore, the use of agents with the ability to control these processes is essential in the search for effective treatments against HPV infections. Glycyrrhizinic acid (Gly), the active ingredient in liquorice, has been shown in numerous preclinical studies to have an antiviral and anticancer activity, reducing the expression of E6 and E7 and inducing apoptosis in cervical cancer cells. In addition, it also has antioxidant, anti-inflammatory, immunomodulatory or re-epithelializing properties that can be useful in HPV infections. This review includes the different antiviral and anticancer mechanisms described for Gly, as well as the clinical studies carried out that position it as a potential therapeutic strategy against HPV both through its topical application and by oral administration.

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“…Licorice is one of the most frequently used plants in traditional Eastern medicine [ 32 , 33 , 34 , 35 ]. GA has been established to be safe for food and medical applications [ 36 , 37 , 38 ] and has a wide range of biological activities such as anti-inflammation, anti-viral, and anticancer activity (see review [ 39 ]). In previous studies, it was demonstrated by various physicochemical methods that the amphiphilic nature of GA allows it to form micelles and gel nanoparticles in aqueous solutions as well as inclusion complexes with drug molecules, thereby enhancing their stability, permeability, and bioavailability [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

NMR Study of Water-Soluble Carotenoid Crocin: Formation of Mixed Micelles, Interaction with Lipid Membrane and Antioxidant Activity

Su,

Mastova,

Ul’yanova

et al. 2024

IJMS

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Crocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin has been shown to have a variety of pharmacological activities, such as antioxidant, anti-cancer, memory improvement, antidepressant, anti-ischemia, blood pressure lowering and aphrodisiac, gene protection and detoxification activities. Due to their amphiphilicity, crocin molecules form concentration-dependent self-associates (micelles) in a water solution. In the present study, using various NMR techniques (T2 relaxation and selective gradient NOESY), we have demonstrated that crocin forms mixed micelles with water-soluble drug delivery system glycyrrhizin and linoleic acid molecules. Note, that the spin–spin T2 relaxation time and NOESY spectroscopy are very sensitive to intermolecular interactions and molecular diffusion mobility. The second purpose of this work was the elucidation of the interaction of crocin with a model lipid membrane using NMR techniques and a molecular dynamics simulation and its effects on lipid oxidation. It was shown that the crocin molecule is located near the surface of the lipid bilayer and effectively protects lipids from oxidation by peroxyl radicals. The role of glycyrrhizin and vitamin C in metal-induced lipid oxidation was also elucidated. The results of this study may be useful for expanding the field of application of crocin in medicine and in the food industry.

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Advances in the roles of glycyrrhizic acid in cancer therapy

Cited by 13 publications

References 119 publications

Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus

NMR Study of Water-Soluble Carotenoid Crocin: Formation of Mixed Micelles, Interaction with Lipid Membrane and Antioxidant Activity

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