Advances in the study of the role of chemokines in drug addiction and the potential effects of traditional Chinese medicines

Liu, Zhuo-Xiu; Wang, Xiao-Qian; Haghparast, Abbas; He, Wen-Bin; Zhang, Jian-Jun

doi:10.1016/j.bbii.2023.100025

Cited by 1 publication

(1 citation statement)

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“…Drugs of abuse directly or indirectly increase the release of dopamine and other neurotransmitters in the brain’s reward system. Neuroanatomically, the reward system in the brain is a complex network of structures and pathways that play a crucial role in motivation, pleasure, and reinforcement of certain behaviors. , The mesolimbic pathway connecting the ventral tegmental area (VTA) with the nucleus accumbens and the mesocortical pathway projecting from the VTA to the prefrontal cortex are mainly involved in rewarding processes . Among the numerous psychoactive substances, amphetamine (AMP), methamphetamine (mAMP), 3,4-methylenedioxymethamphetamine (MDMA), also known as ”ecstasy”, and cocaine (COC) are the most abused drugs.…”

Section: Introductionmentioning

confidence: 99%

Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

Jodłowski,

Dymek,

Kurowski

et al. 2024

ACS Appl. Mater. Interfaces

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The growing number of acute drug abuse overdoses demands the development of innovative detoxification strategies for emergency purposes. In this study, an innovative approach for the application of porous Zr-based metal−organic frameworks for the treatment of acute overdoses of popular drugs of abuse including amphetamine, methamphetamine, cocaine, and MDMA is presented. A comprehensive approach determining the efficacy and the kinetics of drug removal, considering dosage, adsorption time, and adsorption mechanisms, was tested and corroborated with density functional theory (DFT) modeling. The experimental results showed high removal efficiency reaching up to 90% in the case of the application of the NU-1000 metal−organic framework. The difference Raman spectroscopy method presented in this study corroborated with DFT-based vibrational analysis allows the detection of drug adsorbed in the MOF framework even with as low a concentration as 5 mg/g. Additionally, the drug adsorption mechanisms were modeled with DFT, showing the π−π stacking in a vast majority of considered cases. The performance and influence on the living organisms were evaluated throughout the in vitro and in vivo experiments, indicating that Zr-based MOFs could serve as efficient, organic, safe drug adsorbents.

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Section: Introductionmentioning

confidence: 99%