2024
DOI: 10.1038/s41537-024-00485-x
|View full text |Cite
|
Sign up to set email alerts
|

Advances in the study of phencyclidine-induced schizophrenia-like animal models and the underlying neural mechanisms

Dabing Li,
Qiangwen Pan,
Yewei Xiao
et al.

Abstract: Schizophrenia (SZ) is a chronic, severe mental disorder with heterogeneous clinical manifestations and unknown etiology. Research on SZ has long been limited by the low reliability of and ambiguous pathogenesis in schizophrenia animal models. Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist, rapidly induces both positive and negative symptoms of SZ as well as stable SZ-related cognitive impairment in rodents. However, the neural mechanism underlying PCP-induced SZ-like sym… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2
1

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
references
References 136 publications
0
0
0
Order By: Relevance