Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines
Lijuan Liang,
Youjun Mi,
Shihan Zhou
et al.
Abstract:Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers a repair cascade in response to stimuli and pathogenic factors, leading to the activation of molecular signaling pathways involved in fibrosis. This article discusses the key cells, molecules, and signaling pathways implicated in the pathogenesis of RF, with a particular focus on tubular epithelial cells (TECs), cellular senescence, ferroptosis, autophagy, epithelial-mesenchym… Show more
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