Advances in the synthesis and chemical transformations of 5-acetyl-1,3,4-thiadiazolines

Multicomponent synthesis of spiro 1,3,4‐thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation

“…Acetylation of thiosemicarbazones under heating is one of the main ways to obtain 1,3,4-thiadiazolines [31][32][33][34]. This synthetic route leads to the desired products in relatively short reaction times when performed under microwave irradiation, as demonstrated in the literature for obtaining spiro compounds containing oxindolic and 1,3,4-thiadiazolinic nuclei [35].…”