Advances in the therapy of the myelodysplastic syndromes

Kouides, Peter A.; Bennett, John M.

doi:10.1007/978-0-585-38571-6_14

Cited by 2 publications

(2 citation statements)

References 92 publications

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“…A etiologia da síndrome mielodisplási-ca pode estar relacionada tanto a exposição a fatores tóxicos ambientais, como a predisposição genética (mais rara) 10 . A angeíte isolada do SNC, por sua vez, não possui etiologia bem definida.…”

Section: Discussionunclassified

Angeíte isolada do sistema nervoso central em paciente com síndrome mielodisplásica: relato de caso

Silva

Neto

Frota

et al. 2004

Arq. Neuro-Psiquiatr.

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RESUMO -As angeítes isoladas do sistema nervoso central (SNC) são vasculites de pequenos e grandes vasos de etiologia indeterminada que acometem exclusivamente a vasculatura do sistema nervoso. Geralmente não estão associadas a doenças pré-existentes. Relatamos caso de angeíte isolada de SNC em um paciente com diagnóstico hematológico de síndrome mielodisplásica.PALAVRAS-CHAVE: vasculite, sistema nervoso central, síndrome mielodisplásica. Isolated central nervous system angiitis and myelodysplastic syndrome: case reportABSTRACT -Isolated central nervous system (CNS) angiitis are vasculitides of undetermined etiology in which only nervous system vessels are affected. In most cases there is no associated systemic disease. We report the case of a 67 years old man with previous hematologic diagnosis of myelodysplastic syndrome who developed an isolated CNS angiitis.

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Section: Discussionunclassified

Angeíte isolada do sistema nervoso central em paciente com síndrome mielodisplásica: relato de caso

Silva

Neto

Frota

et al. 2004

Arq. Neuro-Psiquiatr.

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“…One of the most important questions to be addressed in patients with freshly diagnosed MDS is whether a curative (aggressive) therapy-approach should be offered [85][86][87][88][89][90]. This question should always be asked and answered at diagnosis or a few weeks (or a few months at the latest) thereafter.…”

Section: Selection Of Patients For Curative (Aggressive) Therapiesmentioning

confidence: 99%

Pathogenesis, classification, and treatment of myelodysplastic syndromes (MDS)

Valent

Wimazal

Schwarzinger

et al. 2003

Wien Klin Wochenschr

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Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal myeloid disorders characterized by morphologic dysplasia in one or more cell lineages. Dysplasia in MDS is associated with insufficient production of blood cells and consecutive cytopenia(s). The natural course and prognosis of MDS vary among patients and depend on genetic defects that occur during clonal evolution. In a significant group of patients (roughly 30%) progression to secondary leukemia is observed. These patients appear to have a grave prognosis. The treatment of patients with MDS has to be adjusted to the individual situation and age in each case. In many patients, control of blast cell production by palliative cytoreduction, continuous support with red blood cells, as well as other supportive measures, seem appropriate. In other patients, however, curative therapy (chemotherapy, stem cell transplantation) should be considered. The final decision to offer curative therapy must be based on many different factors including age and the overall situation of the patient. Recently established scoring systems aimed at predicting survival and evolution of leukemia in MDS may be helpful in this regard.

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Advances in the therapy of the myelodysplastic syndromes

Cited by 2 publications

References 92 publications

Angeíte isolada do sistema nervoso central em paciente com síndrome mielodisplásica: relato de caso

Angeíte isolada do sistema nervoso central em paciente com síndrome mielodisplásica: relato de caso

Pathogenesis, classification, and treatment of myelodysplastic syndromes (MDS)

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