Advances in tissue engineering of gellan gum-based hydrogels

A Gellan Gum, Polyethylene Glycol, Hydroxyapatite Composite Scaffold with the Addition of Ginseng Derived Compound K with Possible Applications in Bone Regeneration

“…Gellan gum within PEG provided a support matrix to integrate the other components. The first material was chosen because of the demonstrated ability to form after freeze-drying a suitable porous microstructure to allow osteoconduction [49], while the second was selected to stabilize the matrix for longer times and to give to the structure a certain degree of tensile strength which is necessary to support other mechanical stresses than compression [50]. Hydroxyapatite was used to improve the mechanical performances in compression and because, being the major mineral component of bone, it favorably impacts the biological outcome [35].…”

Gellan Gum as a Unique Microbial Polysaccharide: Its Characteristics, Synthesis, and Current Application Trends

“…There have been several cutting-edge advancements in the use of GG to develop responsive systems in the field of biomedical applications ( Table 9 ). The latest developments in the use of GG in various biomedical fields demonstrate its ability to advance drug delivery [ 107 , 110 , 111 , 112 ], tissue engineering [ 113 , 114 ], wound healing [ 115 , 116 ], and diagnostics [ 111 , 117 ]. The responsive nature of GG enables the development of specific systems that react to particular physiological signals, enhancing their efficiency and flexibility in different biomedical scenarios.…”

“…Due to GG's capability of producing thermoreversible gels, it enables the development of intricate structures with improved mechanical characteristics, ideal for scaffold production. [113,114,121,122] Wound healing and dressings…”

“…Utilizing the unique properties of GG, it is possible to develop sensing platforms capable of detecting particular biomolecules or variations in physiological conditions. [111,112,114,117,126] Combination with nanoparticles GG can be combined with nanoparticles, like drug-loaded nanoparticles or imaging agents, to develop multifunctional responsive systems with improved therapeutic or diagnostic capabilities.…”

Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)–Glutaraldehyde Mixtures for Fricke Gel Dosimetry

“…In other words, a hydrogel matrix should ensure physical and mechanical integrity to prove effective in its use as biomaterials during the lifetime of an application [ 1 , 2 ]. Because of the advances in hydrogel technologies and their versatile fabrication methods and tunable physical properties, hydrogel materials have been applied in a wide range of biomedical and engineering applications, ranging from cell culturing [ 3 ] to tissue engineering [ 4 , 5 , 6 ], sensors and actuators [ 7 , 8 ], drug delivery [ 9 , 10 ], and so on. In particular, this work focuses on the characterization of hydrogels used for dosimetric applications and, specifically, Fricke gel (FG) dosimetry.…”