Advances in Tracheal Reconstruction

Haykal, Siba; Salna, Michael; Waddell, Thomas K.; Hofer, Stefan O. P.

doi:10.1097/gox.0000000000000097

Cited by 58 publications

(63 citation statements)

References 164 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The attempts of tracheal replacement with free non-vascularized grafts have failed [19]. Lack of revascularization is often the reason of failure [20].…”

Section: Discussionmentioning

confidence: 99%

“…Lack of revascularization is often the reason of failure [20]. Even in tracheal reimplantations made with short segment non-vascularized grafts, cartilage is resorbed and it is replaced by fibrous tissue [19]. When nasal and ear cartilages are used at laryngotracheoplasty, they are rapidly resorbed and can not provide the essential mechanical support [21].…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies show that vascularized homografts including omentopexy, muscle flaps and myocutaneous flaps were found successfully [24-27]. Unfortunately, this studies had short-term follow-up generally and the results of the most of them were with limited success [16,19]. Tissue engineering studies hold promise for both closing the tracheal defects and the replacement of trachea [19,28,29].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis

Aydoğmuş

Topkara

Akbulut

et al. 2016

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

ObjectivesMucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model.MethodsThis randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and trachea-thyroid cartilage anastomosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-tracheal anastomosis using free palatal mucosa graft. Re-stenosis was evaluated after 42 days.ResultsThe percentages of stenosis were 27%±20%, 40%±20%, and 34%±23% for group 1, 2, and 3, respectively and the difference was not statistically significant (P=0.29). Intensive and tight fibrosis was observed in 2 rabbits (13%) in group 1, in 5 rabbits (33%) in group 2, and in 3 rabbits (20%) in group 3. There was not a statistically significant difference between groups (P=0.41). Excessive inflammation was observed in 3 rabbits (20%) in group 1, in 7 rabbits (47%) in group 2, and 3 rabbits (20%) in group 3. There was no a statistically significant difference between groups although inflammation rate was higher in the rabbits which underwent buccal mucosa graft (P=0.18).ConclusionThe surgical treatments applied with free mucosa graft reduced anastomosis tension through enabling anastomosis to the distal of cricoid instead of thyroid cartilage. Free palatal mucosa grafts may be used in sub-glottic field, one of the most challenging fields of trachea surgery, due to ease of application and rapid vascularization.

show abstract

“…The attempts of tracheal replacement with free non-vascularized grafts have failed [19]. Lack of revascularization is often the reason of failure [20].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis

Aydoğmuş

Topkara

Akbulut

et al. 2016

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…Engineers have developed clinically tested biomaterials to regenerate tissues such as the trachea, nasal alar lobule cartilage, bladder, and vaginal wall; however these tissues are either largely avascular or less than 3 mm in thickness. 1–5 One reason for the lack of clinical translation of larger implants is that the standard methods of TE rely on diffusion to transport oxygen throughout the scaffold, which results in higher oxygen concentrations towards scaffold edges and lower concentrations towards the center.…”

Section: Introductionmentioning

confidence: 99%

Oxygen delivering biomaterials for tissue engineering

2016

View full text Add to dashboard Cite

Tissue engineering (TE) has provided promising strategies for regenerating tissue defects, but few TE approaches have been translated for clinical applications. One major barrier in TE is providing adequate oxygen supply to implanted tissue scaffolds, since oxygen diffusion from surrounding vasculature in vivo is limited to the periphery of the scaffolds. Moreover, oxygen is also an important signaling molecule for controlling stem cell differentiation within TE scaffolds. Various technologies have been developed to increase oxygen delivery in vivo and enhance the effectiveness of TE strategies. Such technologies include hyperbaric oxygen therapy, perfluorocarbon- and hemoglobin-based oxygen carriers, and oxygen-generating, peroxide-based materials. Here, we provide an overview of the underlying mechanisms and how these technologies have been utilized for in vivo TE applications. Emerging technologies and future prospects for oxygen delivery in TE are also discussed to evaluate the progress of this field towards clinical translation.

show abstract

“…Previous successful studies have been covered in other reviews. 1,4) In this review, we aim to cover the most recent clinical updates about this subject with emphasis on the most recent innovative methods and endeavors to overcome their limitations.…”

Section: Main Problem and Pathological Backgroundmentioning

confidence: 99%

Current Solutions for Long-Segment Tracheal Reconstruction

Abouarab

Elsayed

Elkhayat

et al. 2017

ATCS

View full text Add to dashboard Cite

This article is a continuation of previous reviews about the appropriate method for long-segment tracheal reconstruction. We attempted to cover the most recent, successful and promising results of the different solutions for reconstruction that are rather innovative and suitable for imminent clinical application. Latest efforts to minimize the limitations associated with each method have been covered as well. In summary, autologous and allogenic tissue reconstruction of the trachea have been successful methods for reconstruction experimentally and clinically. Autologous tissues were best utilized clinically to enhance revascularization, whether as a definitive airway or as an adjunct to allografts or tissue-engineered trachea (TET). Allogenic tissue transplantation is, currently, the most suitable for clinical application, especially after elimination of the need for immunosuppressive therapy with unlimited supply of tissues. Similar results have been reported in many studies that used TET. However, clinical application of this method was limited to use as a salvage treatment in a few studies with promising results. These results still need to be solidified by further clinical and longterm follow-up reports. Combining different methods of reconstruction was often required to establish a physiological rather than an anatomical trachea and have shown superior outcomes.

show abstract

Advances in Tracheal Reconstruction

Cited by 58 publications

References 164 publications

Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis

Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis

Oxygen delivering biomaterials for tissue engineering

Current Solutions for Long-Segment Tracheal Reconstruction

Contact Info

Product

Resources

About