2019
DOI: 10.1016/j.addr.2018.12.006
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Advances in transdermal insulin delivery

Abstract: Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for … Show more

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Cited by 242 publications
(129 citation statements)
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References 255 publications
(258 reference statements)
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“…In the context of insulin delivery systems, transdermal delivery is being explored as a less invasive method of administration. 69 The measured cargo release times from ZIF-based biocomposites are similar to previously reported transdermal delivery systems. 70,71 The difference in the release proles from BSA and insulin suggests that the chemical nature, charge, and size of the protein could inuence defects in the biocomposites.…”
Section: Resultssupporting
confidence: 84%
“…In the context of insulin delivery systems, transdermal delivery is being explored as a less invasive method of administration. 69 The measured cargo release times from ZIF-based biocomposites are similar to previously reported transdermal delivery systems. 70,71 The difference in the release proles from BSA and insulin suggests that the chemical nature, charge, and size of the protein could inuence defects in the biocomposites.…”
Section: Resultssupporting
confidence: 84%
“…Here fOMF stands for the open microchannel surface area fraction. The value of fOMF is unity for the in vitro process and Equation (6) changes to Equation (5). The drug is taken away by the systemic circulation once it crosses the viable skin tissue.…”
Section: Simulation Of Mn Enhanced Tddmentioning
confidence: 99%
“…Since the first demonstration of the applicability of MN in 1998 [1], it has been recognised as an alternative to traditional methods for the delivery of vaccines, drugs and cosmetics [4]. For example, MNs have been employed recently to improve the transdermal permeation of insulin [5], caffeine [6], human growth hormone [7], lidocaine [8], ovalbumin [9], bovine albumin [10], bevacizumab [11], rapamycin [12], Calcein [13], parathyroid hormone [14] and levonorgestrel [15]. MNs have also been explored for the delivery of other molecules such as peptides, ocular drugs and cancer drugs [16].…”
Section: Introductionmentioning
confidence: 99%
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“…In T1DM, the pancreas terminates or reduces insulin production due to pancreatic β-cell destruction, whereas in T2DM, the cells manifest low sensitivity towards insulin and consequently both types lead to hyperglycemia [ 20 ]. Poorly controlled blood glucose levels can bring about serious adverse effects in cardiovascular system, nervous system, retina, and even early death [ 21 , 22 ], hence exogenous insulin intake is imperative in patients with T1DM and advanced T2DM [ 23 ].…”
Section: Introductionmentioning
confidence: 99%