Advances in vaccines: revolutionizing disease prevention

Tripathi, Timir

doi:10.1038/s41598-023-38798-z

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Vaccines play a vital role in preventing infectious diseases by stimulating the immune system to recognize and mount a defense against specific pathogens. The lack of effective vaccines leaves individuals susceptible to fungal infections and limits preventive measures ( Brown et al., 2012 ; Tripathi, 2023 ).…”

Section: Virulence Factors and Therapeutic Potential Of Fungal Pathogensmentioning

confidence: 99%

Unveiling the menace: a thorough review of potential pandemic fungal disease

Jafarlou

2024

Front. Fungal Biol.

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Fungal diseases have emerged as a significant global health threat, with the potential to cause widespread outbreaks and significant morbidity and mortality. Anticipating future pandemic fungal diseases is essential for effective preparedness and response strategies. This comprehensive literature review aims to provide a comprehensive analysis of the existing research on this topic. Through an extensive examination of scholarly articles, this review identifies potential fungal pathogens that have the potential to become pandemics in the future. It explores the factors contributing to the emergence and spread of these fungal diseases, including climate change, globalization, and antimicrobial resistance. The review also discusses the challenges in diagnosing and treating these diseases, including limited access to diagnostic tools and antifungal therapies. Furthermore, it examines the strategies and interventions that can be employed to mitigate the impact of future pandemic fungal diseases, such as improved surveillance systems, public health education, and research advancements. The findings of this literature review contribute to our understanding of the potential risks posed by fungal diseases and provide valuable insights for public health professionals and policymakers in effectively preparing for and responding to future pandemic outbreaks. Overall, this review emphasizes the importance of proactive measures and collaborative efforts to anticipate and mitigate the impact of future pandemic fungal diseases.

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Section: Virulence Factors and Therapeutic Potential Of Fungal Pathogensmentioning

confidence: 99%

Unveiling the menace: a thorough review of potential pandemic fungal disease

Jafarlou

2024

Front. Fungal Biol.

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“…Societal confidence in vaccination is a key driver of innovation in the design and conception of novel candidates for clinical translation . Of the major classes of biopolymers that take center stage, carbohydrates have proven to be particularly adept .…”

Section: Introductionmentioning

confidence: 99%

A Fluorinated Sialic Acid Vaccine Lead Against Meningitis B and C

Jordan,

Siebold,

Priegue

et al. 2024

J. Am. Chem. Soc.

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Inspired by the specificity of α-(2,9)-sialyl epitopes in bacterial capsular polysaccharides (CPS), a doubly fluorinated disaccharide has been validated as a vaccine lead against Neisseria meningitidis serogroups C and/or B. Emulating the importance of fluorine in drug discovery, this molecular editing approach serves a multitude of purposes, which range from controlling α-selective chemical sialylation to mitigating competing elimination. Conjugation of the disialoside with two carrier proteins (CRM197 and PorA) enabled a semisynthetic vaccine to be generated; this was then investigated in six groups of six mice. The individual levels of antibodies formed were compared and classified as highly glycan-specific and protective. All glycoconjugates induced a stable and long-term IgG response and binding to the native CPS epitope was achieved. The generated antibodies were protective against MenC and/or MenB; this was validated in vitro by SBA and OPKA assays. By merging the fluorinated glycan epitope of MenC with an outer cell membrane protein of MenB, a bivalent vaccine against both serogroups was created. It is envisaged that validation of this synthetic, fluorinated disialoside bioisostere as a potent antigen will open new therapeutic avenues.

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