Advances of Apetala2/Ethylene Response Factors in Regulating Development and Stress Response in Maize

Qi, Huanhuan; Liang, Kun; Ke, Yinggen; Wang, Jing; Yang, Pingfang; Yu, Feng; Qiu, Fazhan

doi:10.3390/ijms24065416

Cited by 9 publications

(4 citation statements)

References 102 publications

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“…As one of the largest TF families in plants, AP2/ERF (APETALA2/Ethylene Responsive Factor) plays indispensable roles in plant growth, development, hormone regulation, flavonoid synthesis, and especially in responses to various stresses ( Zhang et al., 2020 ; Qian et al., 2022 ; Qi et al., 2023 ). Recently, three AP2/ERF TFs were identified as positive regulators of the chalcone isomerase (CHI) gene that enhanced the accumulation of flavanones and flavones in citrus ( Zhao et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Integration of genome-wide association studies, metabolomics, and transcriptomics reveals phenolic acid- and flavonoid-associated genes and their regulatory elements under drought stress in rapeseed flowers

Salami,

Heidari,

Batley

et al. 2024

Front. Plant Sci.

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IntroductionBiochemical and metabolic processes help plants tolerate the adverse effects of drought. In plants accumulating bioactive compounds, understanding the genetic control of the biosynthesis of biochemical pathways helps the discovery of candidate gene (CG)–metabolite relationships.MethodsThe metabolic profile of flowers in 119 rapeseed (Brassica napus) accessions was assessed over two irrigation treatments, one a well-watered (WW) condition and the other a drought stress (DS) regime. We integrated information gained from 52,157 single-nucleotide polymorphism (SNP) markers, metabolites, and transcriptomes to identify linked SNPs and CGs responsible for the genetic control of flower phenolic compounds and regulatory elements.ResultsIn a genome-wide association study (GWAS), of the SNPs tested, 29,310 SNPs were qualified to assess the population structure and linkage disequilibrium (LD), of which several SNPs for radical scavenging activity (RSA) and total flavanol content (TFLC) were common between the two irrigation conditions and pleiotropic SNPs were found for chlorogenic and coumaric acids content. The principal component analysis (PCA) and stepwise regression showed that chlorogenic acid and epicatechin in WW and myricetin in DS conditions were the most important components for RSA. The hierarchical cluster analysis (HCA) showed that vanillic acid, myricetin, gallic acid, and catechin were closely associated in both irrigation conditions. Analysis of GWAS showed that 60 CGs were identified, of which 18 were involved in stress-induced pathways, phenylpropanoid pathway, and flavonoid modifications. Of the CGs, PAL1, CHI, UGT89B1, FLS3, CCR1, and CYP75B137 contributed to flavonoid biosynthetic pathways. The results of RNA sequencing (RNA-seq) revealed that the transcript levels of PAL, CHI, and CYP75B137 known as early flavonoid biosynthesis-related genes and FLS3, CCR1, and UGT89B1 related to the later stages were increased during drought conditions. The transcription factors (TFs) NAC035 and ERF119 related to flavonoids and phenolic acids were upregulated under drought conditions.DiscussionThese findings expand our knowledge on the response mechanisms to DS, particularly regarding the regulation of key phenolic biosynthetic genes in rapeseed. Our data also provided specific linked SNPs for marker-assisted selection (MAS) programs and CGs as resources toward realizing metabolomics-associated breeding of rapeseed.

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Section: Discussionmentioning

confidence: 99%

Integration of genome-wide association studies, metabolomics, and transcriptomics reveals phenolic acid- and flavonoid-associated genes and their regulatory elements under drought stress in rapeseed flowers

Salami,

Heidari,

Batley

et al. 2024

Front. Plant Sci.

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“…Plant hormones play an important role in plant growth and developmental processes [29][30][31]. Qi et al reported that OsEATB restricts the ethylene-induced enhancement of gibberellin responsiveness and promotes the branching potential of both tillers and spikelets in rice [32,33]. In the present study, the ethylene signaling pathway activator (Os04g0456900) was also shown to be significantly upregulated based on the results of RNA-seq analysis in the rice lines with ETV traits, and the sequence alignment results showed two amino acids inserted in the T461 genome compared to WYG genome.…”

Section: Ethylene May Play An Important Role In Etv Traits Of Ricementioning

confidence: 99%

The QTL and Candidate Genes Regulating the Early Tillering Vigor Traits of Late-Season Rice in Double-Cropping Systems

Wu,

Zhang,

You

et al. 2024

IJMS

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Rice effective panicle is a major trait for grain yield and is affected by both the genetic tiller numbers and the early tillering vigor (ETV) traits to survive environmental adversities. The mechanism behind tiller bud formation has been well described, while the genes and the molecular mechanism underlying rice-regulating ETV traits are unclear. In this study, the candidate genes in regulating ETV traits have been sought by quantitative trait locus (QTL) mapping and bulk-segregation analysis by resequencing method (BSA-seq) conjoint analysis using rice backcross inbred line (BIL) populations, which were cultivated as late-season rice of double-cropping rice systems. By QTL mapping, seven QTLs were detected on chromosomes 1, 3, 4, and 9, with the logarithm of the odds (LOD) values ranging from 3.52 to 7.57 and explained 3.23% to 12.98% of the observed phenotypic variance. By BSA-seq analysis, seven QTLs on chromosomes 1, 2, 4, 5, 7, and 9 were identified using single-nucleotide polymorphism (SNP) and insertions/deletions (InDel) index algorithm and Euclidean distance (ED) algorithm. The overlapping QTL resulting from QTL mapping and BSA-seq analysis was shown in a 1.39 Mb interval on chromosome 4. In the overlap interval, six genes, including the functional unknown genes Os04g0455650, Os04g0470901, Os04g0500600, and ethylene-insensitive 3 (Os04g0456900), sialyltransferase family domain containing protein (Os04g0506800), and ATOZI1 (Os04g0497300), showed the differential expression between ETV rice lines and late tillering vigor (LTV) rice lines and have a missense base mutation in the genomic DNA sequences of the parents. We speculate that the six genes are the candidate genes regulating the ETV trait in rice, which provides a research basis for revealing the molecular mechanism behind the ETV traits in rice.

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“…Moreover, AP2/ERFs also play key roles in regulating plant responses to various biotic and abiotic stresses, including salinity, drought, temperature, and multiple pathogens (e.g. viruses, fungi, and bacteria) (Qi, et al 2023 ; Xie, et al 2019 ). AP2/ERF superfamily is traditionally considered to specifically exist in plants, until its orthologs have been identified in genomes of microbes, such as the cyanobacterium Trichodesmium erythraeum , the virus Enterobacteria phage Rb49 (Magnani, et al 2004 ; Wessler 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Plant disease resistance outputs regulated by AP2/ERF transcription factor family

Ma,

Sun,

et al. 2024

Stress Biology

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Plants have evolved a complex and elaborate signaling network to respond appropriately to the pathogen invasion by regulating expression of defensive genes through certain transcription factors. The APETALA2/ethylene response factor (AP2/ERF) family members have been determined as key regulators in growth, development, and stress responses in plants. Moreover, a growing body of evidence has demonstrated the critical roles of AP2/ERFs in plant disease resistance. In this review, we describe recent advances for the function of AP2/ERFs in defense responses against microbial pathogens. We summarize that AP2/ERFs are involved in plant disease resistance by acting downstream of mitogen activated protein kinase (MAPK) cascades, and regulating expression of genes associated with hormonal signaling pathways, biosynthesis of secondary metabolites, and formation of physical barriers in an MAPK-dependent or -independent manner. The present review provides a multidimensional perspective on the functions of AP2/ERFs in plant disease resistance, which will facilitate the understanding and future investigation on the roles of AP2/ERFs in plant immunity.

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Advances of Apetala2/Ethylene Response Factors in Regulating Development and Stress Response in Maize

Cited by 9 publications

References 102 publications

Integration of genome-wide association studies, metabolomics, and transcriptomics reveals phenolic acid- and flavonoid-associated genes and their regulatory elements under drought stress in rapeseed flowers

Integration of genome-wide association studies, metabolomics, and transcriptomics reveals phenolic acid- and flavonoid-associated genes and their regulatory elements under drought stress in rapeseed flowers

The QTL and Candidate Genes Regulating the Early Tillering Vigor Traits of Late-Season Rice in Double-Cropping Systems

Plant disease resistance outputs regulated by AP2/ERF transcription factor family

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