Advances of Blood Coagulation Factor XIII in Bone Healing

Dang, Yi; Zhang, Yi; Jian, Minghui; Luo, Ping; Anwar, Nadia; Ma, Yaping; Zhang, Dingmei; Wang, Xin

doi:10.1089/ten.teb.2023.0016

Cited by 3 publications

(3 citation statements)

References 103 publications

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“…Activated FXIII cross-links fibrin monomers and α2-plasmin inhibitors to fibrin, thereby increasing the clot resistance to mechanical stress and fibrinolysis. [7,25–29] Excessive consumption of FXIII consumption due to trauma and surgery may increase the risk of postoperative bleeding. [27,30] FXIII plays essential roles in hemostasis, angiogenesis, wound healing, bone regeneration, and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…[7,25–29] Excessive consumption of FXIII consumption due to trauma and surgery may increase the risk of postoperative bleeding. [27,30] FXIII plays essential roles in hemostasis, angiogenesis, wound healing, bone regeneration, and inflammation. [25,27,30–32] Patients with FXIIID may have physiologically normal results on routine coagulation tests; therefore, laboratory testing for FXIII activity is necessary in the presence of abnormal bleeding.…”

Section: Discussionmentioning

confidence: 99%

“…[ 27 , 30 ] FXIII plays essential roles in hemostasis, angiogenesis, wound healing, bone regeneration, and inflammation. [ 25 , 27 , 30 – 32 ] Patients with FXIIID may have physiologically normal results on routine coagulation tests; therefore, laboratory testing for FXIII activity is necessary in the presence of abnormal bleeding. [ 13 ] In clinical practice, standardized activity tests based on transglutaminase activity, isopeptidase activity, direct quantitative antigen assays, coagulative resolution tests, or autoantibody assays are more feasible, and molecular genetics should be performed if necessary.…”

Section: Discussionmentioning

confidence: 99%

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Abnormal bleeding after lumbar vertebrae surgery because of acquired factor XIII deficiency: A case report and literature review

Zhang,

Jing

2024

Medicine

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Rationale: Abnormal bleeding due to low fibrinogen (Fib) and coagulation factor XIII (FXIII) levels after lumbar vertebral surgery is exceedingly rare. Excessive bleeding is also associated with secondary hyperfibrinolysis. This report presents a case of abnormal incision bleeding caused by coagulation factor XIII deficiency (FXIIID) and secondary hyperfibrinolysis in a state of low fibrinogen after lumbar vertebral surgery. Patient concerns: A middle-aged woman experienced prolonged incision and excessive bleeding after lumbar vertebral surgery. Diagnosis: Combined with coagulation factors, coagulation function tests, and thromboelastography, the patient clinical presentation supported the diagnosis of FXIIID and secondary hyperfibrinolysis in a hypofibrinogenemic state. Interventions: Cryoprecipitat, Fresh Frozen Plasma, Fibrinogen Concentrate, Leukocyte-depleted Red Blood Cells, Hemostatic (Carbazochrome Sodium Sulfonate; Hemocoagulase Bothrops Atrox for Injection; Tranexamic Acid). Outcomes: After approximately a month of replacement therapy and symptom treatment, the patient coagulation function significantly improved, and the incision healed without any hemorrhage during follow-up. Lessons: Abnormal postoperative bleeding may indicate coagulation and fibrinolysis disorders that require a full set of coagulation tests, particularly coagulation factors. Given the current lack of a comprehensive approach to detect coagulation and fibrinolysis functions, a more comprehensive understanding of hematology is imperative. The current treatment for FXIIID involves replacement therapy, which requires supplementation with both Fib and FXIII to achieve effective hemostasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Abnormal bleeding after lumbar vertebrae surgery because of acquired factor XIII deficiency: A case report and literature review

Zhang,

Jing

2024

Medicine

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Carboxypeptidase M modulates BMSCs osteogenesis–adipogenesis via the MAPK/ERK pathway: An integrated single‐cell and bulk transcriptomic study

Liao,

Zheng,

et al. 2024

The FASEB Journal

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The pathogenesis of osteoporosis (OP) is closely associated with the disrupted balance between osteogenesis and adipogenesis in bone marrow‐derived mesenchymal stem cells (BMSCs). We analyzed published single‐cell RNA sequencing (scRNA‐seq) data to dissect the transcriptomic profiles of bone marrow‐derived cells in OP, reviewing 56 377 cells across eight scRNA‐seq datasets from femoral heads (osteoporosis or osteopenia n = 5, osteoarthritis n = 3). Seventeen genes, including carboxypeptidase M (CPM), were identified as key osteogenesis‐adipogenesis regulators through comprehensive gene set enrichment, differential expression, regulon activity, and pseudotime analyses. In vitro, CPM knockdown reduced osteogenesis and promoted adipogenesis in BMSCs, while adenovirus‐mediated CPM overexpression had the reverse effects. In vivo, intraosseous injection of CPM‐overexpressing BMSCs mitigated bone loss in ovariectomized mice. Integrated scRNA‐seq and bulk RNA sequencing analyses provided insight into the MAPK/ERK pathway's role in the CPM‐mediated regulation of BMSC osteogenesis and adipogenesis; specifically, CPM overexpression enhanced MAPK/ERK signaling and osteogenesis. In contrast, the ERK1/2 inhibitor binimetinib negated the effects of CPM overexpression. Overall, our findings identify CPM as a pivotal regulator of BMSC differentiation, which provides new clues for the mechanistic study of OP.

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Unlocking the potential of stimuli-responsive biomaterials for bone regeneration

Yang,

Wu,

Zhang

et al. 2024

Front. Pharmacol.

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Bone defects caused by tumors, osteoarthritis, and osteoporosis attract great attention. Because of outstanding biocompatibility, osteogenesis promotion, and less secondary infection incidence ratio, stimuli-responsive biomaterials are increasingly used to manage this issue. These biomaterials respond to certain stimuli, changing their mechanical properties, shape, or drug release rate accordingly. Thereafter, the activated materials exert instructive or triggering effects on cells and tissues, match the properties of the original bone tissues, establish tight connection with ambient hard tissue, and provide suitable mechanical strength. In this review, basic definitions of different categories of stimuli-responsive biomaterials are presented. Moreover, possible mechanisms, advanced studies, and pros and cons of each classification are discussed and analyzed. This review aims to provide an outlook on the future developments in stimuli-responsive biomaterials.

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Advances of Blood Coagulation Factor XIII in Bone Healing

Cited by 3 publications

References 103 publications

Abnormal bleeding after lumbar vertebrae surgery because of acquired factor XIII deficiency: A case report and literature review

Abnormal bleeding after lumbar vertebrae surgery because of acquired factor XIII deficiency: A case report and literature review

Carboxypeptidase M modulates BMSCs osteogenesis–adipogenesis via the MAPK/ERK pathway: An integrated single‐cell and bulk transcriptomic study

Unlocking the potential of stimuli-responsive biomaterials for bone regeneration

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