Advances of microfluidic lung chips for assessing atmospheric pollutants exposure

Wang, Hui; Yin, Fangchao; Li, Zhongyu; Su, Wentao; Li, Dong

doi:10.1016/j.envint.2023.107801

Cited by 17 publications

(15 citation statements)

References 105 publications

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“…The technique of temperature-driven switching of bistable flow enriches the active regulation of flow, which has great potential in the fields of mechanical engineering [ 32 ], bioengineering [ 33 ], medical engineering [ 34 ], and other relevant fields.…”

Section: Discussionmentioning

confidence: 99%

Flow Characteristics and Switching Mechanism of Bistable Slit Flow Actuated by Temperature

Nie

et al. 2023

Entropy

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The bistable flow is attractive as it can be analogous to a switch to realize flow control. Based on the previous studies on actuation technique, the present study first proposed temperature-driven switching of bistable slit flow. A two-dimensional numerical simulation was conducted to investigate the flow deflection characteristics and switching mechanism. It was concluded that the temperature gradient not only biases the slit flow but also locks it to the high-temperature side. The flow deflection angle became larger with the increase in temperature gradient. Being driven by the temperature, the flow can be switched from one side to the other. Furthermore, the fluid viscosity, which varies with temperature, determines the degree of flow deflection and the entire switching time. This research can enrich the active regulation of flow and has significant potential applications in thermal sensors, thermal detectors, microelectromechanical systems, biomedicine, and other equivalent fields.

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Section: Discussionmentioning

confidence: 99%

Flow Characteristics and Switching Mechanism of Bistable Slit Flow Actuated by Temperature

Nie

et al. 2023

Entropy

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“…Prominently, OrgOCs technology can significantly increase reliability in the prediction of drug efficacy and safety, while reducing the cost and drug failure rate, potentially providing strong scientific evidence for clinical trials. These features are not available with conventional 2D cell culture and animal models, where there are obvious mismatches between the data derived from animal and human, or from in vitro static and in vivo dynamic conditions 38 , 54 , 139 .…”

Section: Snapshot Of Oocs Hos and Orgocsmentioning

confidence: 99%

“…These are the most basic and simplest methods to reconstruct a self-organized microvascular network of organs in vivo . At present, a series of functional organ barriers with vascularization features have been reproduced, including the blood-brain barrier, placental barrier and capillary vessel barrier 38 , 51 , 53 , 209 , 210 . Not limited to these, a real sense of engineered vascularized organs, that are vascularized organoids, are formed following the same strategy.…”

Section: Progress Of Orgocs In Biomedical Applicationsmentioning

confidence: 99%

Human organoids-on-chips for biomedical research and applications

Wang,

Ning,

Zhao

et al. 2024

Theranostics

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Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs) technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic characteristics of organs, such as environmental clues of living tissue, while HOs are more amenable to biological analysis and genetic manipulation. By spatial cooperation, OrgOCs served as 3D organotypic living models allowing them to recapitulate critical tissue-specific properties and forecast human responses and outcomes. It represents a giant leap forward from the regular 2D cell monolayers and animal models in the improved human ecological niche modeling. In recent years, OrgOCs have offered potential promises for clinical studies and advanced the preclinical-to-clinical translation in medical and industrial fields. In this review, we highlight the cutting-edge achievements in OrgOCs, introduce the key features of OrgOCs architectures, and share the revolutionary applications in basic biology, disease modeling, preclinical assay and precision medicine. Furthermore, we discuss how to combine a wide range of disciplines with OrgOCs and accelerate translational applications, as well as the challenges and opportunities of OrgOCs in biomedical research and applications.

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“…Rapid and ultra-sensitive pollutant testing using environmentally friendly, easy to operate and low-cost technologies is a promising strategy to achieve a sustainable ecological balance. [138][139][140][141] In this case, lignin-based carbon quantum dots (CQDS) as uorescence sensors show great potential in terms of non-toxicity, excellent water solubility, adjustable uorescence characteristics and fast response. Some researchers have synthesized nanomaterials using different types of lignin, e.g., cellulose decomposing enzymes lignin, lignosulfonate lignin and alkali lignin, to detect expensive metal ions.…”

Section: Substance Testingmentioning

confidence: 99%