Advances of Microneedles in Biomedical Applications

Xu, Jie; Xu, Danfeng; Xuan, Xuan; He, Huacheng

doi:10.3390/molecules26195912

Cited by 81 publications

(41 citation statements)

References 124 publications

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“…With hollow MNs, it is technically possible to control the flow and dosing by diffusion or pressure or electronically (e.g., using a pump), and to integrate them into lab-on-chip devices. Similarly, bio-macromolecules, including proteins, vaccines, mRNA, and diagnostic agents, can be delivered via hollow MNs [50,51]. These MNs can also be used for the isolation and identification of biomarkers including glucose [52], and ECG measurements [53].…”

Section: Microneedle-based Delivery Approachesmentioning

confidence: 99%

Microneedles in Drug Delivery: Progress and Challenges

Avcil¹,

Çelik²

2021

Micromachines

140

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In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The advantages of microneedle patch technology have been extensively evaluated in the latest literature; hence, the academic publications in this area are rising exponentially. Like all new technologies, the microneedle patch application has great potential but is not without limitations. In this review, we will discuss the possible limitations by highlighting the areas where a great deal of improvements are required. Emphasising these concerns early on should help scientists and technologists to address the matters in a timely fashion and to use their resources wisely.

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Section: Microneedle-based Delivery Approachesmentioning

confidence: 99%

Microneedles in Drug Delivery: Progress and Challenges

Avcil¹,

Çelik²

2021

Micromachines

140

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“…These tiny projections are arranged in arrays on top of a baseplate. When compared to other types of microneedles, dissolving microneedles made from a variety of materials, such as sugars and biodegradable polymers, exhibit many advantages, including patient acceptance; greater control over the release profile; and the ability to convincingly incorporate small drugs, large macromolecules, and nanoparticles (7) . To achieve effective transdermal delivery of anastrozole within therapeutic concentration to induce tissue effect, we prepared anastrozole as polymeric nanoparticles to be loaded into dissolving microneedles, thereby combining the benefits of polymeric nanoparticles and dissolving microneedles while avoiding their drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Anastrozole Nanoparticles for Transdermal Delivery through Microneedles: Preparation and Evaluation

2022

pnr

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This study examined transdermal anastrozole (ANA) as an oral alternative. ANA is a nonsteroidal aromatase inhibitor licensed to treat breast cancer and metastatic disease. Estrogen makes breast cancer worse. However, ANA is only available as a once-daily oral tablet. In this work, dissolving microneedles that were loaded with ANA polymeric nanoparticles allowed for the transdermal distribution of anastrozole. Method: ANA polymeric nanoparticles were created by the nanoprecipitation process utilizing the polymeric matrix kollicoat MAE100-55, and their physical characteristics and in-vitro release were investigated. Using different water-soluble polymers and the micro-molding method, four formulas of dissolving microneedles loaded with ANA polymeric nanoparticles were created. Additionally, the prepared needles' morphology, mechanical strength, moisture uptake percentage, and moisture loss percentage were examined. Result: The ANA polymeric nanoparticles are 50.49±7.9nm in size, have a polydispersity index of 0.19±0.07, and have an entrapment efficiency of 75±4.5%. While employing poloxamer188 as a stabilizer, complete drug release took place in 3.5 hours. Among the various polymers used to make dissolving microneedle formulas, M-2 made from PVA demonstrated superior mechanical strength, moisture loss percentage, and moisture uptake. Ex vivo permeation through abdominal rat skin confirmed the penetration-enhancing impact of microneedles as permeation increased by 4.9 times compared to bare skin. Histology found no inflammatory reactions or cellular pathology with needle penetration. Conclusion: It was possible to successfully manufacture polymeric nanoparticles of ANA and load them onto dissolving microneedles with sufficient mechanical strength to penetrate the stratum corneum and permit nanoparticle transdermal delivery.

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“…All microneedles were 600 µm in length, with 300 µm for the base cross sections and 30 µm for the tip, separated by 1.85 mm (measured from tip-to-tip). The Microneedles were constructed with patches of an 11*11 array affixed to a solid 15x15x1 mm substrate [30,31]. Further, this array was examined and verified with the given literature and this array was drafted in a CAD.…”

Section: Furnishing Of the Cadd Design For Fabrication Of Microneedlesmentioning

confidence: 99%

Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Kaur

Thakur

Goswami³

2022

Int J App Pharm

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Objective: This study's goals were to develop a minimally invasive array of biocompatible polymeric solid microneedles and formulate a transdermal patch of drug Ɣ-Oryzanol as per poke and patch technology. Methods: Scanning electron microscopy was used to analyse the morphology of the solid microneedle arrays, which were created using a stereolithography (SLA) printer with high-resolution capabilities (25 and 140 microns for the z and x axes, respectively). Transdermal Patches of Ɣ-Oryzanol were formulated and evaluated for various characterization parameters. Further, the produced microneedle-transdermal drug delivery system of Ɣ-Oryzanol was examined for microneedle insertion skin and permeation of the drug across the porcine skin. Results: Solid microneedle arrays were manufactured using biocompatible Class I Dental SG resin having dimensions of 600 µm height and 300 µm width with tip diameters of 30 µm and 1.85 mm interspacing (Distance from tip to tip) and they were strong enough to penetrate porcine skin to a depth of 381.356 µm crossing the stratum corneum layer without causing any structural changes. Transdermal patches containing Ɣ-Oryzanol were formulated using different ratios of HPMC: Eudragit E-100. Good, consistent, and transparent films were formulated when the thickness of the film ranges between 0.516±0.25-0.628±0.21 mm, average weights ranged from 168.23±2.61to171.22±1.25(10/cm2), folding endurance ranged in between 10 folds to 12 folds for all the formulations with tensile strength lie between the 0.365 kg/mm2 to 0.465 kg/mm2. All the formulations showed good drug content between 99.3±0.06%-90.4±1.64% with 100% flat surfaces. Moisture content was found in the range of 2.012±0.013 to 4.213±0.031. Drug permeation studies reveal that compound Ɣ-Oryzanol transdermal patches didn’t show significant permeation across porcine skin (4.802.25 g/cm2) without piercing with microneedles while after poking skin using microneedles (74.502.35 g/cm2) drug showed good penetration properties. It was found that the amount of drug delivered increased to 44.251.57 g/cm2 at 2 min, which was 14.502.35 g/cm2 at 1 min to 4 min 74.502.35 g/cm2. Conclusion: Successful preparation of the Microneedle-Transdermal drug delivery system of Ɣ-Oryzanol and their evaluation indicated that the quality and consistency of the formulated preparation were excellent. With advantages in terms of lowered dose frequency, better patient compliance, and bioavailability, this may find use in the therapeutic field.

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Advances of Microneedles in Biomedical Applications

Cited by 81 publications

References 124 publications

Microneedles in Drug Delivery: Progress and Challenges

Microneedles in Drug Delivery: Progress and Challenges

Anastrozole Nanoparticles for Transdermal Delivery through Microneedles: Preparation and Evaluation

Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

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