Advances of molecularly imprinted polymers (MIP) and the application in drug delivery

He, Suna; Zhang, Liping; Bai, Shangkun; Yang, Hui; Cui, Zheng; Zhang, Xiaofei; Li, Yuanpei

doi:10.1016/j.eurpolymj.2020.110179

Cited by 147 publications

(76 citation statements)

References 79 publications

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“…In this study, MIP were synthesized by the bulk polymerization method (He et al, 2021). During the experiments, MIP of 3 proportions were synthesized by changing the ratio of the template molecule and the functional monomer MAA.…”

Section: Synthesis Of Mipmentioning

confidence: 99%

Chemiluminescence sensors based on molecularly imprinted polymers for the determination of organophosphorus in milk

Pan

Liu

et al. 2022

Journal of Dairy Science

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As a food adapted to all kinds of people, milk has a high nutritional value. Because milk is a complex biological matrix, detecting illegal compounds is often difficult. As a common pesticide, organophosphorus (OP) residues caused by nonstandard use may be ignored, which is a threat to milk quality. In this study, using coumaphos as template molecule, the synthesized molecularly imprinted polymer (MIP) can specifically recognize 7 kinds of OP. Then, the MIP was used as an identification element to prepare a chemiluminescence sensor on a 96-well microplate for the determination of OP residues in milk samples. Due to the 4-(imidazol-1-yl)phenol-enhanced luminol-H 2 O 2 system, the sensitivity of the system is very high; the detection limits of 7 OP including coumaphos, fenthion, chlorpyrifos, parathion, diazinon, fenchlorphos, and fenitrothion were 1 to 3 pg/mL, and the half maximal inhibitory concentrations were 1 to 20 ng/mL. The intraday recoveries of 7 OP were in the range of 86.1 to 86.5%, and the interday recoveries were in the range of 83.6 to 94.2%. Furthermore, the sensor can be reused up to 5 times. Therefore, the MIP-based chemiluminescence sensor can be used as a routine tool to detect OP residues in milk samples.

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Section: Synthesis Of Mipmentioning

confidence: 99%

Chemiluminescence sensors based on molecularly imprinted polymers for the determination of organophosphorus in milk

Pan

Liu

et al. 2022

Journal of Dairy Science

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“…Although MIPs-based DDSs have not been translated to the clinic yet, the molecular imprinting technology has a great potential to create ideal dosage forms. A good proof is that publications devoted to the use of MIPs in the design of novel DDSs and devices are gradually increasing [63][64][65]. Although the number of studies on drug delivery related to molecular imprinting is still limited, the studies on MIP-based drug delivery have increased significantly in the past five years, with more than 50% of the papers on drug delivery related to molecular imprinting published on PubMed during this time span, which indicates the increasing interest in the use of molecular imprinting vehicles as DDSs (Figure 2).…”

Section: The Rationale Of Mips Used In Drug Deliverymentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Li¹,

Poma

2021

Molecules

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Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

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“…In the first decades, the development and application of MIPs were mainly focused on separation and extraction techniques. Nowadays, MIPs are used in a wide variety of applications, including sample preparation (e.g., solid phase extraction) [ 12 , 13 ] chromatographic separation [ 14 ], chemical sensing [ 15 ], and drug delivery [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

et al. 2021

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Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

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Advances of molecularly imprinted polymers (MIP) and the application in drug delivery

Cited by 147 publications

References 79 publications

Chemiluminescence sensors based on molecularly imprinted polymers for the determination of organophosphorus in milk

Chemiluminescence sensors based on molecularly imprinted polymers for the determination of organophosphorus in milk

Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

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