Advances of typical mesoporous materials and the application in drug delivery

Abstract

For the excellent drug delivery systems, advanced functional materials are indispensable. In recent years, mesoporous materials have shown a promising prospect and attracted much attention in the field of drug delivery. The research of mesoporous materials as drug carriers becomes to be a hotspots. As a drug vehicle, it is favored by scientists due to the advantages in increasing drug dissolution and bioavailability, improving drug stability, sustained and controlled drug release, reducing drug side effects, good biocompatibility, targeting and so on. The anticipated in vivo performance for the mesoporous materials based drug delivery systems can be improved through optimizing the synthesis conditions or modifying the materials. In the paper, mesoporous silica nanoparticles (MSNs), mesoporous carbon nanoparticles (MCNs), organic frameworks (OFs), mesoporous hydroxyapatite (mHAp) were selected as the representative mesoporous materials. The structural characteristics, preparation methods, application in the field of drug delivery of above materials were reviewed, and the future research was prospected.

Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique

“…Kesse et al and He et al, stated that mesoporous mannitol as drug delivery has several advantages, including increasing drug dissolution and bioavailability, increasing drug stability, controlled and sustained drug release, reducing side effects, and having good biocompatibility [31], [32].…”