Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors

Abstract

As the major bioactive compound of Scutellaria baicalensis that has been approved to be effective as an anti-inflammatory and antiviral inhibitor in cardiovascular diseases, wogonin (WG) showed potent and promising antitumor effects both in vitro and in vivo. It has been proved that WG has the ability to inhibit the growth of tumor cells, induce apoptosis, and suppress angiogenesis. The molecular mechanisms involve reactive oxygen species, Ca2+, NF-κB, tumor necrosis factor-related apoptosis-inducing ligand, and tumor necrosis factor-alpha. Furthermore, the synergistic effect of WG with 5-fluorouracil, etoposide, and adriamycin to enhance chemotherapy and reverse drug resistance has also been confirmed. In this review, we summarize the advances in recent years on the antitumor effect of WG on multiple tumors; in addition, we also present information regarding the synergistic and chemosensitizing effects of WG with other drugs to illustrate its potential use in the clinic.

Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport

“…Wogonin has been used as a treatment for cancers and ocular diseases [ 9 , 10 ]. In these previous studies, wogonin exhibited antitumor effects by inhibiting the extracellular regulated protein kinase and Wnt/beta-catenin pathways.…”

“…In recent years, melanization has again gained attention as a risk factor for melanoma [ 41 ]. Several studies have shown the antitumor effect of wogonin on multiple tumors, including melanomas [ 9 , 10 ]. Zhao et al used in vitro and in vivo assays to show that wogonin inhibits the cell invasion of metastatic melanoma by suppressing the PI3K/AKT and NF-κB pathways [ 42 ].…”

“…Scutellaria baicalensis Georgi is a perennial herb belonging to the Lamiaceae family. Its root has been used as a traditional Chinese medicine to alleviate inflammation, allergy, and fever as well as a treatment for several cancers [ 9 , 10 ]. Various bioactive components, such as flavonoids, have been identified in S .…”

Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis

“…S. baicalensis injection is the only herbal medication extract that has been recommended by the Guidelines for the Diagnosis and Treatment of HFMD (2012 edition, China). In previous studies, S. baicalensis demonstrated effective anti-inflammatory and antiviral activities in the treatment of cancer and viral infectious diseases [13–15]. In addition, previous studies have suggested that these effects of S. baicalensis were associated with the regulation of multiple molecular pathways, including reactive oxygen species, Ca 2+ , nuclear factor- κ B, and tumor necrosis factor-related apoptosis-inducing ligand [16–19].…”

A systematic review of herbal medicines for the treatment of cancer cachexia in animal models

“…Scutellariae Radix, the root of the medicinal plant S. baicalensis, has been widely used for various diseases. S. baicalensis shows many therapeutic effects, including tumor growth inhibition, apoptosis induction, and anti-angiogenesis (Li et al, 2011;Muluye et al, 2014;Wu et al, 2016). Chou et al (2012) reported that the oral administration of QSYQT water extract to Lewis lung cancer cell-bearing mice significantly prevented weight loss without affecting food intake or tumor growth.…”