Advances on Natural Abietane, Labdane and Clerodane Diterpenes as Anti-Cancer Agents: Sources and Mechanisms of Action

Acquaviva, Rosaria; Malfa, Giuseppe Antonio; Loizzo, Monica Rosa; Xiao, Jianbo; Bianchi, Simone; Tundis, Rosa

doi:10.3390/molecules27154791

Cited by 26 publications

(15 citation statements)

References 137 publications

(144 reference statements)

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“…It is not the first time that corymbulosins, clerodane diterpenes with an isozuelanin skeleton, exhibit this kind of activity, encouraging a deeper understanding of the mechanisms of action. Corymbylosin A, X, and M were highlighted in a recent review concerning the potential anti-cancer activities of diterpenes with abietane, labdane, and clerodane skeletons [ 33 ]. Corymbulosin X, isolated from Anacolasa clarkii exhibits high activity against some pediatric cancer cell lines [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactive Clerodane Diterpenoids from the Leaves of Casearia coriacea Vent

et al. 2023

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Casearia coriacea Vent., an endemic plant from the Mascarene Islands, was investigated following its antiplasmodial potentialities highlighted during a previous screening. Three clerodane diterpene compounds were isolated and identified as being responsible for the antiplasmodial activity of the leaves of the plant: caseamembrin T (1), corybulosin I (2), and isocaseamembrin E (3), which exhibited half maximal inhibitory concentrations (IC50) of 0.25 to 0.51 µg/mL. These compounds were tested on two other parasites, Leishmania mexicana mexicana and Trypanosoma brucei brucei, to identify possible selectivity in one of them. Although these products possess both antileishmanial and antitrypanosomal properties, they displayed selectivity for the malaria parasite, with a selectivity index between 6 and 12 regarding antitrypanosomal activity and between 25 and 100 regarding antileishmanial activity. These compounds were tested on three cell lines, breast cancer cells MDA-MB-231, pulmonary adenocarcinoma cells A549, and pancreatic carcinoma cells PANC-1, to evaluate their selectivity towards Plasmodium. This has not enabled us to establish selectivity for Plasmodium, but has revealed the promising activity of compounds 1–3 (IC50 < 2 µg/mL), particularly against pancreatic carcinoma cells (IC50 < 1 µg/mL). The toxicity of the main compound, caseamembrin T (1), was then evaluated on zebrafish embryos to extend our cytotoxicity study to normal, non-cancerous cells. This highlighted the non-negligible toxicity of caseamembrin T (1).

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Section: Resultsmentioning

confidence: 99%

Bioactive Clerodane Diterpenoids from the Leaves of Casearia coriacea Vent

et al. 2023

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“…They are widely found in nature and are defined as compounds having various pharmacological activities ( Kemboi et al., 2021 ). For example, it has been reported by various researchers that diterpenes obtained from the plants belonging to the genus Taxus are used in the treatment of prostate, ovarian, lung, and breast cancer ( Chen et al., 2021 ; Acquaviva et al., 2022 ; Tomiotto-Pellissier et al., 2022 ).…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Production of secondary metabolites using tissue culture-based biotechnological applications

et al. 2023

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Plants are the sources of many bioactive secondary metabolites which are present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to the plants in many cases, they are not necessary for metabolisms related to growth, development, and reproduction. They are specific to plant species and are precursor substances, which can be modified for generations of various compounds in different plant species. Secondary metabolites are used in many industries, including dye, food processing and cosmetic industries, and in agricultural control as well as being used as pharmaceutical raw materials by humans. For this reason, the demand is high; therefore, they are needed to be obtained in large volumes and the large productions can be achieved using biotechnological methods in addition to production, being done with classical methods. For this, plant biotechnology can be put in action through using different methods. The most important of these methods include tissue culture and gene transfer. The genetically modified plants are agriculturally more productive and are commercially more effective and are valuable tools for industrial and medical purposes as well as being the sources of many secondary metabolites of therapeutic importance. With plant tissue culture applications, which are also the first step in obtaining transgenic plants with having desirable characteristics, it is possible to produce specific secondary metabolites in large-scale through using whole plants or using specific tissues of these plants in laboratory conditions. Currently, many studies are going on this subject, and some of them receiving attention are found to be taken place in plant biotechnology and having promising applications. In this work, particularly benefits of secondary metabolites, and their productions through tissue culture-based biotechnological applications are discussed using literature with presence of current studies.

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“…Chemoprevention is a powerful method to prevent or slow down cancer progression ( Acquaviva et al, 2022 ). In addition, many herbal medicines and related active compounds with potent anticancer activity, such as matrine and honokiol have been used as prophylactic agents.…”

Section: Cancer and Chemopreventionmentioning

confidence: 99%

Salvianolic acid B from Salvia miltiorrhiza bunge: A potential antitumor agent

Guo

Wang

2022

Front. Pharmacol.

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Salvia miltiorrhiza Bunge (Lamiaceae) is a perennial herb widely found in China since ancient times with a high economic and medicinal value. Salvianolic acid B (Sal-B) is an important natural product derived from Salvia miltiorrhiza and this review summarizes the anticancer activity of Sal-B. Sal-B inhibits tumor growth and metastasis by targeting multiple cell signaling pathways. This review aims to review experimental studies to describe the possible anticancer mechanisms of Sal-B and confirm its potential as a therapeutic drug.

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Advances on Natural Abietane, Labdane and Clerodane Diterpenes as Anti-Cancer Agents: Sources and Mechanisms of Action

Cited by 26 publications

References 137 publications

Bioactive Clerodane Diterpenoids from the Leaves of Casearia coriacea Vent

Bioactive Clerodane Diterpenoids from the Leaves of Casearia coriacea Vent

Production of secondary metabolites using tissue culture-based biotechnological applications

Salvianolic acid B from Salvia miltiorrhiza bunge: A potential antitumor agent

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