Advances on Porous Nanomaterials for Biomedical Application (Drug Delivery, Sensing, and Tissue Engineering)

Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications

“…Our study unambiguously demonstrates that mPDA encapsulation is a versatile platform, which will extend the applications of FNDs into a wider variety of biomedical fields. This may include challenging applications such as targeted in vitro sensing in cellular structures. , Besides, the large surface area of the pores in the mPDA shell will offer improved performances as a contrast agent, a therapeutic medicine, and a catalyst. − …”

Indocyanine Green-Loaded Mesoporous Silica Nanocomposite for Breast Cancer Imaging

“…Among them, porous nanomaterials, particularly mesoporous silica nanoparticles (MSNs), are highly suitable for biomedical applications, including imaging, smart drug delivery, and diagnostic integration. The key factors contributing to their ordered pore structure, narrow pore size distribution, large surface area and volume, high-density silanol groups with favorable covalent bonding with organic groups, and excellent biocompatibility and degradability. − In recent studies, superparamagnetic mesoporous nanomicrospheres of MSNs encapsulating magnetite nanoparticles have been successfully employed for specific targeting of tumor regions in nude mice with pancreatic cancer. This significant development paves the way for the use of multimodal imaging in the early detection and diagnosis of pancreatic cancer .…”

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier

“…Therefore, to achieve better therapeutic action, the drug materials are required to bind with some carrier materials for the targeted drug delivery process . Two types of carriers generally work in the drug delivery system: one is the organic carrier, which includes polymer materials, micelles, liposomes, and protein nanoparticles, and the other includes porous materials such as zeolites, mesoporous silica, etc. − The porous materials are advantageous over other organic carriers due to their well-defined porosity and flexibility, which help in greater loading of drug molecules as well as their controlled release. , Despite various types of mesoporous materials, metal organic frameworks (also called supramolecular solids) are extensively used as drug carriers, as they possess a regular porosity, a large pore volume, flexible pore sizes with high thermal and chemical stability, and organic functionality. ,, They are constructed by metal atoms or metal clusters, called secondary building units (SBUs), connected with multidentate organic ligands with coordinate bonds . Structurally, metal organic frameworks contain hydrophilic and hydrophobic units, which help to tune their pore sizes and also help the guest molecules to interact with them.…”

“… 2 − 6 The porous materials are advantageous over other organic carriers due to their well-defined porosity and flexibility, which help in greater loading of drug molecules as well as their controlled release. 7 , 8 Despite various types of mesoporous materials, metal organic frameworks (also called supramolecular solids) are extensively used as drug carriers, as they possess a regular porosity, a large pore volume, flexible pore sizes with high thermal and chemical stability, and organic functionality. 1 , 9 , 10 They are constructed by metal atoms or metal clusters, called secondary building units (SBUs), connected with multidentate organic ligands with coordinate bonds.…”