Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

Yang, Qingyi; Zheng, Wenqian; Zhao, Yuping; Shi, Yaru; Wang, Yi; Sun, Hongchen; Xu, Xiaowei

doi:10.1016/j.dental.2024.06.013

Dental Materials

2024

DOI: 10.1016/j.dental.2024.06.013

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Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

Qingyi Yang,

Wenqian Zheng,

Yuping Zhao

et al.

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Cited by 4 publications

References 170 publications

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The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems

Breschi,

Maravic,

Mazzitelli

et al. 2024

Dental Materials

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The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems

Breschi,

Maravic,

Mazzitelli

et al. 2024

Dental Materials

View full text Add to dashboard Cite

Remineralisation of mineral-deficient dentine induced by experimental ion-releasing materials in combination with a biomimetic dual-analogue primer

Chou,

Maciel Pires,

Alambiaga-Caravaca

et al. 2025

Journal of Dentistry

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Non-collagenous protein analog-induced biomimetic mineralization strategy to restore the dentin interface

Chen,

Xie,

et al. 2024

Biomed. Phys. Eng. Express

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Dentin biomineralization is a gene-regulated, cytokine-mediated, and programmed process by mineralized cells to form highly ordered hydroxyapatite (HAP) crystals encapsulating dentin matrix, ultimately building a stable dentin interface. Repairing dentin damage caused by irreversible demineralization has been a challenge in dental regenerative medicine due to dentin’s limited biomineralization ability. It is well established that non-collagenous proteins (NCPs)-collagen interactions and NCPs-crystal interactions influence the nucleation, deposition, arrangement, and assembly of HAP crystals during the biomineralization process. Inspired by this process, NCP analogs can be used as a biomimetic template to stabilize the intermediate mineral phases of biomineralization to achieve collagen fibrils’ hierarchical mineralization in dentin. In addition, specific functional groups can be introduced to achieve antimicrobial, anti-enzymatic, and cross-linking functions to restore the microstructure and mechanical properties of demineralized dentin. Therefore, the design and development of NCP analogs are currently a hot topic in dentin biomimetic restorations. However, most existing reviews have only focused on the mineralization effect of NCP analogs and have rarely summarized their additional functions and applications at the dentin interface. This review first summarizes the basic principles of dentin biomineralization and biomimetic mineralization and then focuses on the common classifications of NCP analogs and newly introduced functional properties. It finally discusses the applications and limitations of NCP analogs in dentin interface, providing a theoretical basis for applying NCP analogs in the minimally invasive treatment of demineralized dentin.

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Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

Cited by 4 publications

References 170 publications

The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems

The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems

Remineralisation of mineral-deficient dentine induced by experimental ion-releasing materials in combination with a biomimetic dual-analogue primer

Non-collagenous protein analog-induced biomimetic mineralization strategy to restore the dentin interface

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