2023
DOI: 10.1016/j.biosx.2022.100288
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Advancing electrochemical biosensors for interleukin-6 detection

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Cited by 20 publications
(37 citation statements)
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“…An overview of electrochemical sensors targeting salivary biomarkers was published by Mani et al [ 98 ]. Several electrochemical biosensors have been developed for the detection of ILs [ 99 ] and specifically for IL-8, as a biomarker of oral cancer and other types of cancer. The normal concentration of IL-8 in human saliva is in the 200–300 pg mL −1 range, whereas patients suffering from oral cavity and oropharyngeal squamous cell carcinoma have IL-8 concentrations higher than 720 pg mL −1 [ 100 , 101 ].…”
Section: Oral Microbiomementioning
confidence: 99%
“…An overview of electrochemical sensors targeting salivary biomarkers was published by Mani et al [ 98 ]. Several electrochemical biosensors have been developed for the detection of ILs [ 99 ] and specifically for IL-8, as a biomarker of oral cancer and other types of cancer. The normal concentration of IL-8 in human saliva is in the 200–300 pg mL −1 range, whereas patients suffering from oral cavity and oropharyngeal squamous cell carcinoma have IL-8 concentrations higher than 720 pg mL −1 [ 100 , 101 ].…”
Section: Oral Microbiomementioning
confidence: 99%
“…Data processing using advanced machine learning and AI is also challenging, particularly for predicting chronic diseases [ 47 , 69 ]. For chronic pain management, data scientists and healthcare professionals not only need to analyze and interpret the data for -THC and CBD [ 47 , 71 ], but also other biomarkers such as glutamate [ 72 , 73 ] and interleukin-6 [ 74 ], which are associated with chronic pain. Overall, there is significant potential for creating wearable electrochemical -THC and CBD sensors.…”
Section: Research Challenges and Future Perspectivesmentioning
confidence: 99%
“…25 It is crucial to note that the spatial configuration of the biorecognition element significantly influences the biorecognition event. 26 Currently available electrochemical biosensors often face sensitivity and specificity constraints due to the limited availability of active sites with proper orientations for effective biorecognition. Additionally, non-specific interactions with interferents, especially proteins, present in the sample fluids pose a significant risk of producing false-positive results.…”
Section: Introductionmentioning
confidence: 99%