2024
DOI: 10.3390/ph17111439
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Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings

Yahya I. Asiri,
Sivakumar S. Moni,
Mohankumar Ramar
et al.

Abstract: Despite major advancements in our understanding of its fundamental causes, pain—both acute and chronic—remains a serious health concern. Various preclinical investigations utilizing diverse animal, cellular, and alternative models are required and frequently demanded by regulatory approval bodies to bridge the gap between the lab and the clinic. Investigating naturally occurring painful disorders can speed up medication development at the preclinical and clinical levels by illuminating molecular pathways. A wi… Show more

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