Light emitting diodes (LEDs) have experienced rapid technological development in the past decade, making them a winning alternative to conventional light sources in many applications. LED arrays allow precise control of the desired irradiance profile in a target area by adjusting the position and output power of individual LEDs. However, despite increased efficiency, many LEDs still transform a large proportion of the input electrical power into heat, requiring an efficient cooling system. This paper presents a modular LED array light source mounted on a water-cooled aluminum plate. Novel electronic LED driver modules, connected via a serial communication bus in a daisy-chain topology, were developed with the ability to set the operating current of individual LEDs. A modular layout of cooling and mounting system and LED driver modules, as well as a specialized design for the LED soldering footprint, was able to house a variety of common commercial LEDs, enabling easy adjustment of the lighting system to the required application and size of the irradiated area. In a prototype of one plate containing 10 LEDs, individual LED radiance was optimized for a better irradiance homogeneity in the target area. Array characterization showed a low standard deviation of the irradiance of 1.8% and a good fit between measured and calculated irradiance. A test of the array at elevated temperatures showed moderate LED radiance degradation and a wavelength shift of the measured spectra after extended use.