Advancing skin delivery of α-tocopherol and γ-tocotrienol for dermatitis treatment via nanotechnology and microwave technology

Harun, Mohd S.; Wong, Tin Wui; Fong, Chee Wai

doi:10.1016/j.ijpharm.2020.120099

Cited by 17 publications

(10 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…300 This delivery mechanism presents a de novo treatment modality in skin diseases because targeted delivery of gamma-tocotrienol to the skin had proven to be more effective in alleviating dermatitis symptoms. 300 Wound healing is yet another function of tocotrienol treatment. 301 Mice exposed to deep-partial thickness burns were treated with TRF as a cream combined with epidermal growth factor (EGF) and macroscopic and microscopic images of the skin were analyzed along with tests on biochemical parameters.…”

Section: Skin Diseasementioning

confidence: 99%

Revisiting the therapeutic potential of tocotrienol

2022

View full text Add to dashboard Cite

The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a dietary supplement. It is largely considered to be safe when consumed at low doses for attenuating pathophysiology as shown by animal models, in vitro assays, and ongoing human trials. Medical researchers and the allied sciences have experimented with tocotrienols for many decades, but its therapeutic potential was limited to adjuvant or concurrent treatment regimens. Recent studies have focused on targeted drug delivery by enhancing the bioavailability through carriers, self‐sustained emulsions, nanoparticles, and ethosomes. Epigenetic modulation and computer remodeling are other means that will help increase chemosensitivity. This review will focus on the systemic intracellular anti‐cancer, antioxidant, and anti‐inflammatory mechanisms that are stimulated and/or regulated by tocotrienols while highlighting its potent therapeutic properties in a diverse group of clinical diseases.

show abstract

Section: Skin Diseasementioning

confidence: 99%

Revisiting the therapeutic potential of tocotrienol

2022

View full text Add to dashboard Cite

show abstract

“…As shown in Figure 4S , approximately 40% of the Vitamin E content was released after 24 hours, mostly within the first 9 hours (30–35%), in agreement with data recorded for water-rich O/W nanoemulsion obtained by α-tocopherol/deionized water. 65 Both Almond-based and Neem-based formulations displayed the same release profile, despite the chemical-physical difference in oil nanodroplets. This could be explained by considering that the two systems have similar nature once in the presence of Vitamin E, as evidenced by SAXS results.…”

Section: Resultsmentioning

confidence: 96%

Neem Oil or Almond Oil Nanoemulsions for Vitamin E Delivery: From Structural Evaluation to in vivo Assessment of Antioxidant and Anti-Inflammatory Activity

Rinaldi¹,

Hanieh²,

Maurizi³

et al. 2022

IJN

View full text Add to dashboard Cite

Purpose: Vitamin E (VitE) may be classified in "the first line of defense" against the formation of reactive oxygen species. Its inclusion in nanoemulsions (NEs) is a promising alternative to increase its bioavailability. The aim of this study was to compare O/W NEs including VitE based on Almond or Neem oil, showing themselves antioxidant properties. The potential synergy of the antioxidant activities of oils and vitamin E, co-formulated in NEs, was explored. Patients and Methods: NEs have been prepared by sonication and deeply characterized evaluating size, ζ-potential, morphology (TEM and SAXS analyses), oil nanodroplet feature, and stability. Antioxidant activity has been evaluated in vitro, in non-tumorigenic HaCaT keratinocytes, and in vivo through fluorescence analysis of C. elegans transgenic strain. Moreover, on healthy human volunteers, skin tolerability and anti-inflammatory activity were evaluated by measuring the reduction of the skin erythema induced by the application of a skin chemical irritant (methyl-nicotinate). Results: Results confirm that Vitamin E can be formulated in highly stable NEs showing good antioxidant activity on keratinocyte and on C. elegans. Interestingly, only Neem oil NEs showed some anti-inflammatory activity on healthy volunteers. Conclusion: From the obtained results, Neem over Almond oil is a more appropriate candidate for further studies on this application.

show abstract

“…More recently, α-tocopherol and γ-tocotrienol were loaded in nanoemulsions to treat dermatitis as an attempt to avoid the use of steroid anti-inflammatory drugs. This nanotechnological formulation could be in the future an alternative to dermatitis patients [59].…”

Section: Nanotechnology-based Formulationsmentioning

confidence: 99%

Vitamin E and Derivatives in Skin Health Promotion

Santos¹,

Tavares²,

Barradas³

2021

Biochemistry

View full text Add to dashboard Cite

Vitamin E is fundamental for a proper function of human cells. Mostly obtained from vegetable oils, it has antioxidant and non-antioxidant actions. At times, its oral intake or skin application are employed. Oral intake is recommended in some cases. Differently, the topical application is a part of daily skin routine. Both in oral or in topical formulations, it is employed in its isoforms or derivatives. Tocopherols and tocotrienols are isoforms while derivatives are synthetic forms. In pharmaceutical and cosmetic formulations, vitamin E and its derivatives are widely used due to its antioxidant and photoprotective properties. However, the clinical success treatment is often impaired by its low skin penetration, high lipophilicity, and chemical instability. A rational formulation design in the development of novel vitamin E dosage forms is required. In this chapter, the most successful and innovative approaches towards Vitamin E and its derivatives loaded in formulations for skin health promotion are reviewed. Conventional and nanoparticle-based formulations enable vitamin E chemical stabilization, and they are suitable vehicles for its release on the skin. Further, nano-sized carriers can increase vitamin E content in formulations as well as favor its skin penetration.

show abstract

Advancing skin delivery of α-tocopherol and γ-tocotrienol for dermatitis treatment via nanotechnology and microwave technology

Cited by 17 publications

References 55 publications

Revisiting the therapeutic potential of tocotrienol

Revisiting the therapeutic potential of tocotrienol

Neem Oil or Almond Oil Nanoemulsions for Vitamin E Delivery: From Structural Evaluation to in vivo Assessment of Antioxidant and Anti-Inflammatory Activity

Vitamin E and Derivatives in Skin Health Promotion

Contact Info

Product

Resources

About