Advancing the pH hypothesis of negative feedback to photoreceptors: sources of protons and a role for bicarbonate in feedback

Country, Michael William

doi:10.1113/jp273518

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Instead of centripetal tendencies, the questions related to the search of common assessment methods of stability and transition processes of dynamic systems continue to disintegrate into many separate directions. And each such direction requires the theory [19], deepening within the separate research [20] or the private solution [21].…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

Development of structure and method of effective binary stabilization of quality parameter in dynamic systems

Lutsenko

2018

EEJET

View full text Add to dashboard Cite

Section: Literature Review and Problem Statementmentioning

confidence: 99%

Development of structure and method of effective binary stabilization of quality parameter in dynamic systems

Lutsenko

2018

EEJET

View full text Add to dashboard Cite

A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement

Baer

Chang

Crook

et al. 2021

Journal of Theoretical Biology

View full text Add to dashboard Cite

ATP-mediated increase in H⁺ flux from retinal Müller cells: a role for Na⁺/H⁺ exchange

Tchernookova

Gongwer

St.George

et al. 2021

Journal of Neurophysiology

View full text Add to dashboard Cite

Small alterations in extracellular H+ can profoundly alter neurotransmitter release by neurons. We examined mechanisms by which extracellular ATP induces an extracellular H+ flux from Müller glial cells, which surround synaptic connections throughout the vertebrate retina. Müller glia were isolated from tiger salamander retinae and H+ fluxes examined using self-referencing H+-selective microelectrodes. Experiments were performed in 1 mM HEPES with no bicarbonate present. Replacement of extracellular sodium by choline decreased H+ efflux induced by 10 µM ATP by 75%. ATP-induced H+ efflux was also reduced by Na+/H+ exchange inhibitors. Amiloride reduced H+ efflux initiated by 10 µM ATP by 60%, while 10 µM cariporide decreased by 37%, and 25 µM zoniporide reduced H+ flux by 32%. ATP-induced H+ fluxes were not significantly altered by the K+/H+ pump blockers SCH28080 or TAK438, and replacement of all extracellular chloride with gluconate was without effect on H+ fluxes. Recordings of ATP-induced H+ efflux from cells simultaneously whole-cell voltage-clamped revealed no effect of membrane potential from -70 mV to 0 mV. Restoration of extracellular potassium after cells were bathed in 0 mM potassium produced a transient alteration in ATP-dependent H+ efflux. The transient response to extracellular potassium occurred only when extracellular sodium was present and was abolished by 1 mM ouabain, suggesting alterations in sodium gradients mediated by Na+/K ATPase activity. Our data indicate that the majority of H+ efflux elicited by extracellular ATP from isolated Müller cells is mediated by Na+/H+ exchange.

show abstract

Advancing the pH hypothesis of negative feedback to photoreceptors: sources of protons and a role for bicarbonate in feedback

Cited by 3 publications

References 5 publications

Development of structure and method of effective binary stabilization of quality parameter in dynamic systems

Development of structure and method of effective binary stabilization of quality parameter in dynamic systems

A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement

ATP-mediated increase in H⁺ flux from retinal Müller cells: a role for Na⁺/H⁺ exchange

Contact Info

Product

Resources

About

Advancing the pH hypothesis of negative feedback to photoreceptors: sources of protons and a role for bicarbonate in feedback

Cited by 3 publications

References 5 publications

Development of structure and method of effective binary stabilization of quality parameter in dynamic systems

Development of structure and method of effective binary stabilization of quality parameter in dynamic systems

A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement

ATP-mediated increase in H+ flux from retinal Müller cells: a role for Na+/H+ exchange

Contact Info

Product

Resources

About

ATP-mediated increase in H⁺ flux from retinal Müller cells: a role for Na⁺/H⁺ exchange