Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions

Namba, Mark D.; Xie, Qiaowei; Barker, Jacqueline M.

doi:10.1016/j.bbi.2023.07.021

Cited by 10 publications

(8 citation statements)

References 323 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One notable difference includes the absence of gp120, which is a known mediator of deleterious immune and neural outcomes in HIV-1 infection (Gemma et al, 2000;Hill et al, 2019). While consistent with general peripheral and CNS immune system dysregulation observed in rodent models of HIV (Fitting et al, 2013;Melendez et al, 2016;Namba et al, 2023a), the time course of EcoHIV infection differs from HIV-1 (Gu et al, 2018). In the current study, we report that EcoHIV-infected mice showed viral DNA burdens of up to 0.3-5 x 10 3 viral DNA copies per 10 6 spleen cells with 5 weeks of infection.…”

Section: Discussionmentioning

confidence: 87%

“…Together, these findings point to a need to understand the independent and interactive effects of HIV infection and ART on peripheral and CNS immune outcomes, necessitating preclinical models of HIV (Buch et al, 2011; Gorantla et al, 2012; Edagwa et al, 2014; Namba et al, 2023a). To accomplish this, the current study utilized the EcoHIV infection mouse model, in which a chimeric virus is generated by replacing the coding region of the HIV-1 glycoprotein gp120 with that of gp80 (Potash et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

Xie,

Namba,

Buck

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

HIV infection is an ongoing global health issue despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. It is increasingly evident that ART may act independently or in combination with HIV infection to alter immune state, though this is difficult to disentangle in the clinical population. Thus, these experiments used multiplexed chemokine/cytokine arrays to assess peripheral (plasma) and brain (nucleus accumbens; NAc) expression of immune targets in the presence and absence of ART treatment in the EcoHIV mouse model. The findings identify effects of EcoHIV infection and of treatment with bictegravir (B), emtricitabine (F) and tenofovir alafenamide (TAF) on expression of numerous immune targets. In the NAc, this included EcoHIV-induced increases in IL-1α and IL-13 expression and B/F/TAF-induced reductions in KC/CXCL1. In the periphery, EcoHIV suppressed IL-6 and LIF expression, while B/F/TAF reduced IL-12p40 expression. In absence of ART, IBA-1 expression was negatively correlated with CX3CL1 expression in the NAc of EcoHIV-infected mice. These findings identify distinct effects of ART and EcoHIV infection on peripheral and central immune factors and emphasize the need to consider ART effects on neural and immune outcomes.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

Xie,

Namba,

Buck

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…By employing computational and mathematical techniques, scientists can predict a protein’s structure, stability, and activity. This information can lead to the identification of novel drug targets for diseases such as cancer, HIV, and Alzheimer’s , and improve the development of new drug therapies. , Accurate and efficient protein function prediction methods are urgently needed, and further research is required to develop and apply these methods to a broader range of biological processes.…”

Section: Introductionmentioning

confidence: 99%

MSF-PFP: A Novel Multisource Feature Fusion Model for Protein Function Prediction

Li,

Qian,

et al. 2024

J. Chem. Inf. Model.

View full text Add to dashboard Cite

Protein function prediction is essential for disease treatment and drug development; yet, traditional biological experimental methods are less efficient in annotating protein function, and existing automated methods fail to fully leverage protein multisource data. Here, we present MSF-PFP, a computational framework that fuses multisource data features to predict protein function with high accuracy. Our framework designs specific models for feature extraction based on the characteristics of various data sources, including a global-local-individual strategy for local location features. MSF-PFP then integrates extracted features through a multisource feature fusion model, ultimately categorizing protein functions. Experimental results demonstrate that MSF-PFP outperforms eight state-of-the-art models, achieving F Max scores of 0.542, 0.675, and 0.624 for the biological process (BP), molecular function (MF), and cellular component (CC), respectively. The source code and data set for MSF-PFP are available at https://swanhub.co/TianGua/MSF-PFP, facilitating further exploration and validation of the proposed framework. This study highlights the potential of multisource data fusion in enhancing protein function prediction, contributing to improved disease therapy and medication discovery strategies.

show abstract

“…Infectious diseases, including Acquired Immune Deficiency Syndrome, tuberculosis, and COVID-19, contribute to substance abuse and addictive disorders [ [1] , [2] , [3] ]. Lyme disease/Lyme borreliosis (LD) and addictive disorders have been reviewed [ 4 ], and studies show an association between LD and substance abuse [ [5] , [6] , [7] , [8] ], with some people becoming dependent upon psychoactive substances [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Late-stage borreliosis and substance abuse

Bransfield,

Goud Gadila,

Kursawe

et al. 2024

Heliyon

View full text Add to dashboard Cite

Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions

Cited by 10 publications

References 323 publications

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

MSF-PFP: A Novel Multisource Feature Fusion Model for Protein Function Prediction

Late-stage borreliosis and substance abuse

Contact Info

Product

Resources

About