“…Related prior research has focused on gendered differences in chemistry achievement ,, and persistence in chemistry majors, while others have explored differences among ethnicities in STEM access and achievement at both the high school ,, and undergraduate levels. , Intersectional research has often examined women of color in STEM generally, physics/astronomy, and engineering, mostly in undergraduate, graduate, or vocational contexts. ,, Research has identified sources of cognitive challenges in learning AP Chemistry, including higher-level problem solving, connecting macroscopic observations to particulate models, and applying mental algorithms to novel or unfamiliar chemical phenomena. , However, this does not explain demographic differences in coursetaking and achievement. Intersectional research suggests disparate science participation and performance may be related to sociocultural issues such as structural institutional inequities, a culture of marginalization, and hierarchical stereotypes. ,, The intersectional hypothesis was applied in the present study to examine precollege student participation and performance in AP Chemistry, which is consequential in terms of college chemistry readiness and improving diversity in the STEM academic pipeline and workforce . This framework is represented in Figure .…”