Advantage of Ischemic Preconditioning for Hepatic Resection in Pigs

Kadono, Jun; Hamada, Nobuo; Fukueda, Mikio; Ishizaki, Naoki; Kaieda, Mamoru; Gejima, Kentaro; Nishida, Seigo; Nakamura, Kazuo; Yoshida, Hiroki; Sakata, Ryuzo

doi:10.1016/j.jss.2006.02.001

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…IP is a phenomenon in which single or multiple brief periods of ischemia have been shown to protect certain organs against a more prolonged ischemic insult [17]. The beneficial effect of IP on liver IR injury has also been demonstrated, not only in experimental models [19][20][21], but also in clinical hepatic resection [22]. However, the exact cause of this beneficial effect is uncertain.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Nicorandil on Ischemia-Reperfusion Injury in a Porcine Total Hepatic Vascular Exclusion Model

Yamazaki

Oshima

Sato

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

The Effect of Nicorandil on Ischemia-Reperfusion Injury in a Porcine Total Hepatic Vascular Exclusion Model

Yamazaki

Oshima

Sato

et al. 2011

Journal of Surgical Research

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“…Court et al reported the first porcine model of posthepatectomy SFS, which consisted of a left trisectionectomy without portal clamping in order to avoid ischemia of the liver remnant [20]. The same model was further reproduced in several other studies on portal hyperperfusion [7,[21][22][23][24][25][26][27][28][29][30]. However, despite inducing portal hyperperfusion (as defined by an increase of portal vein flow above 250 ml/min per 100 g of liver tissue), the left trisectionectomy model does not seem suitable for studying the SFS syndrome.…”

Section: Porcine Models Of Small-for-size Hepatectomymentioning

confidence: 99%

“…Earlier studies reporting a surgical modality of PIM after extended hepatectomy did not assess the effects of the shunt on the SFS process, but were rather designed to create a postoperative liver failure model and assess the impact of warm ischemia on liver regeneration, without the interaction of portal hyperperfusion. For instance, two different studies by Smyrniotis et al and by Kadono et al assessed the effects of ischemic preconditioning and intermittent vascular clamping on liver regeneration after left trisectionectomy of more than 65% [25,47]. In both studies, a porto-caval shunt was performed using either a 5 mm Gore-tex graft or a direct side-to-side anastomosis in order to avoid hepatic congestion, but the aim was not to assess the efficacy of the shunt, and therefore, there was no control group.…”

Section: After Partial Hepatectomy For Studying the Effects Of Warm Imentioning

confidence: 99%

Porcine models for the study of small‐for‐size syndrome and portal inflow modulation: literature review and proposal for a standardized nomenclature

Mohkam

Darnis

Mabrut

2016

J Hepato Biliary Pancreat

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Porcine models of extended hepatectomy and liver transplantation (LT) of reduced graft have been widely used for studying the small-for-size (SFS) syndrome and the various modalities of portal inflow modulation (PIM). However, considerable heterogeneity exists among the studies and their results. The aim of this review was to assess the main advantages and drawbacks of the different porcine models of SFS LT and SFS hepatectomy, and propose a standardized anatomical nomenclature for the various models. The MEDLINE database was searched for articles reporting porcine models of reduced graft LT or hepatectomy of more than 65%. Nineteen articles on SFS LT matched our inclusion criteria, including 10 articles reporting a model of PIM. Twenty-seven articles reporting a model of posthepatectomy SFS were identified, of which 16 reported a model of PIM. Subtotal hepatectomy (i.e. resection of all segments except segment 1) without inflow occlusion, left trisectionectomy with inflow occlusion, and LT of a right lateral section including the caudate lobe in a larger recipient appeared to be the most suitable porcine models for studying the SFS syndrome. All three models were appropriate for assessing the surgical and pharmaceutical PIM modalities, except for those involving the splenic flow.

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“…However, there was no improvement in serum enzyme levels. On the other hand, Kadono et al 23 and Shimoda et al 24 demonstrated decreased reperfusion injury after IP in a pig model of hepatic resection.…”

Section: Mechanical Preconditioningmentioning

confidence: 98%

Ischemia/reperfusion injury in liver resection: A review of preconditioning methods

et al. 2011

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Ischemic preconditioning is one of the therapeutic interventions aiming at preventing ischemia/reperfusion-related injury. Numerous experimental studies and a few clinical series have shown that during liver resections, ischemic preconditioning is a promising strategy for optimizing the postoperative outcome. Moreover, various types of pharmacological intervention as well as different types of preconditioning, such as remote preconditioning, the use of heat shock, and hyperbaric oxygen, have been developed to attenuate the functional impairment accompanying ischemia/reperfusion injury. This review summarizes the various forms of preconditioning, thus suggesting that close cooperation between surgeons and anesthesiologists paves the way to apply novel strategies to improve the outcome of liver resection.

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Advantage of Ischemic Preconditioning for Hepatic Resection in Pigs

Cited by 10 publications

References 32 publications

The Effect of Nicorandil on Ischemia-Reperfusion Injury in a Porcine Total Hepatic Vascular Exclusion Model

The Effect of Nicorandil on Ischemia-Reperfusion Injury in a Porcine Total Hepatic Vascular Exclusion Model

Porcine models for the study of small‐for‐size syndrome and portal inflow modulation: literature review and proposal for a standardized nomenclature

Ischemia/reperfusion injury in liver resection: A review of preconditioning methods

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